The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia worldwide. β-amyloid
peptide (Aβ) is currently assumed to be the main cause of synaptic dysfunction and cognitive …
peptide (Aβ) is currently assumed to be the main cause of synaptic dysfunction and cognitive …
CREB: a multifaceted target for Alzheimer's disease
Alzheimer's disease (AD) is a persistent neuropathological stipulation manifested in the form
of neuronal/synapse demise, the formation of senile plaques, hyperphosphorylated tau …
of neuronal/synapse demise, the formation of senile plaques, hyperphosphorylated tau …
CREB expression mediates amyloid β-induced basal BDNF downregulation
E Rosa, M Fahnestock - Neurobiology of aging, 2015 - Elsevier
In Alzheimer's disease, accumulation of amyloid-β (Aβ) is associated with loss of brain-
derived neurotrophic factor (BDNF), synapses, and memory. Previous work demonstrated …
derived neurotrophic factor (BDNF), synapses, and memory. Previous work demonstrated …
Brain-derived neurotrophic factor in Alzheimer's disease: risk, mechanisms, and therapy
JH Song, JT Yu, L Tan - Molecular neurobiology, 2015 - Springer
Brain-derived neurotrophic factor (BDNF) has a neurotrophic support on neuron of central
nervous system (CNS) and is a key molecule in the maintenance of synaptic plasticity and …
nervous system (CNS) and is a key molecule in the maintenance of synaptic plasticity and …
The role of CREB signaling in Alzheimer's disease and other cognitive disorders
Gene expression changes in the brain affect cognition during normal and pathological
aging. Progress in understanding the cellular processes regulating gene expression …
aging. Progress in understanding the cellular processes regulating gene expression …
Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential
L Gao, Y Zhang, K Sterling, W Song - Translational neurodegeneration, 2022 - Springer
Synaptic abnormalities are a cardinal feature of Alzheimer's disease (AD) that are known to
arise as the disease progresses. A growing body of evidence suggests that pathological …
arise as the disease progresses. A growing body of evidence suggests that pathological …
Investigation of the molecular role of brain-derived neurotrophic factor in Alzheimer's disease
P Girotra, T Behl, A Sehgal, S Singh… - Journal of Molecular …, 2022 - Springer
Brain-derived neurotrophic factor (BDNF), or abrineurin, is a member of the neurotrophin
family of growth factors that acts on both the central and peripheral nervous systems. BDNF …
family of growth factors that acts on both the central and peripheral nervous systems. BDNF …
Born to protect: leveraging BDNF against cognitive deficit in Alzheimer's disease
L Caffino, F Mottarlini, F Fumagalli - CNS drugs, 2020 - Springer
Alzheimer's disease is a chronic neurodegenerative devastating disorder affecting a high
percentage of the population over 65 years of age and causing a relevant emotional, social …
percentage of the population over 65 years of age and causing a relevant emotional, social …
[HTML][HTML] LncRNA BDNF-AS as ceRNA regulates the miR-9-5p/BACE1 pathway affecting neurotoxicity in Alzheimer's disease
Y Ding, W Luan, Z Wang, Y Cao - Archives of gerontology and geriatrics, 2022 - Elsevier
Introduction The long non-coding RNA Brain-derived nutritional factor anti-sense RNA
(BDNF-AS) is a type of anti-sense RNA that has been proven to play a crucial role in the …
(BDNF-AS) is a type of anti-sense RNA that has been proven to play a crucial role in the …
Brain-derived neurotrophic factor signaling in the pathophysiology of Alzheimer's disease: Beneficial effects of flavonoids for neuroprotection
T Numakawa, H Odaka - International Journal of Molecular Sciences, 2021 - mdpi.com
The function of the brain-derived neurotrophic factor (BDNF) via activation through its high-
affinity receptor Tropomyosin receptor kinase B (TrkB) has a pivotal role in cell …
affinity receptor Tropomyosin receptor kinase B (TrkB) has a pivotal role in cell …