The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease

M Amidfar, J de Oliveira, E Kucharska, J Budni, YK Kim - Life sciences, 2020 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia worldwide. β-amyloid
peptide (Aβ) is currently assumed to be the main cause of synaptic dysfunction and cognitive …

CREB: a multifaceted target for Alzheimer's disease

VK Sharma, TG Singh - Current Alzheimer Research, 2020 - ingentaconnect.com
Alzheimer's disease (AD) is a persistent neuropathological stipulation manifested in the form
of neuronal/synapse demise, the formation of senile plaques, hyperphosphorylated tau …

CREB expression mediates amyloid β-induced basal BDNF downregulation

E Rosa, M Fahnestock - Neurobiology of aging, 2015 - Elsevier
In Alzheimer's disease, accumulation of amyloid-β (Aβ) is associated with loss of brain-
derived neurotrophic factor (BDNF), synapses, and memory. Previous work demonstrated …

Brain-derived neurotrophic factor in Alzheimer's disease: risk, mechanisms, and therapy

JH Song, JT Yu, L Tan - Molecular neurobiology, 2015 - Springer
Brain-derived neurotrophic factor (BDNF) has a neurotrophic support on neuron of central
nervous system (CNS) and is a key molecule in the maintenance of synaptic plasticity and …

The role of CREB signaling in Alzheimer's disease and other cognitive disorders

CA Saura, J Valero - 2011 - degruyter.com
Gene expression changes in the brain affect cognition during normal and pathological
aging. Progress in understanding the cellular processes regulating gene expression …

Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential

L Gao, Y Zhang, K Sterling, W Song - Translational neurodegeneration, 2022 - Springer
Synaptic abnormalities are a cardinal feature of Alzheimer's disease (AD) that are known to
arise as the disease progresses. A growing body of evidence suggests that pathological …

Investigation of the molecular role of brain-derived neurotrophic factor in Alzheimer's disease

P Girotra, T Behl, A Sehgal, S Singh… - Journal of Molecular …, 2022 - Springer
Brain-derived neurotrophic factor (BDNF), or abrineurin, is a member of the neurotrophin
family of growth factors that acts on both the central and peripheral nervous systems. BDNF …

Born to protect: leveraging BDNF against cognitive deficit in Alzheimer's disease

L Caffino, F Mottarlini, F Fumagalli - CNS drugs, 2020 - Springer
Alzheimer's disease is a chronic neurodegenerative devastating disorder affecting a high
percentage of the population over 65 years of age and causing a relevant emotional, social …

[HTML][HTML] LncRNA BDNF-AS as ceRNA regulates the miR-9-5p/BACE1 pathway affecting neurotoxicity in Alzheimer's disease

Y Ding, W Luan, Z Wang, Y Cao - Archives of gerontology and geriatrics, 2022 - Elsevier
Introduction The long non-coding RNA Brain-derived nutritional factor anti-sense RNA
(BDNF-AS) is a type of anti-sense RNA that has been proven to play a crucial role in the …

Brain-derived neurotrophic factor signaling in the pathophysiology of Alzheimer's disease: Beneficial effects of flavonoids for neuroprotection

T Numakawa, H Odaka - International Journal of Molecular Sciences, 2021 - mdpi.com
The function of the brain-derived neurotrophic factor (BDNF) via activation through its high-
affinity receptor Tropomyosin receptor kinase B (TrkB) has a pivotal role in cell …