Purpose MTHFR, one of the major enzymes in the folate cycle, is known to acquire single-
nucleotide polymorphisms that significantly reduce its activity, resulting in an increase in …

Abstract Purpose Methyltetrahydrofolate reductase (MTHFR) C677T (ala222Val) is a single-
nucleotide polymorphism (SNP) that affects the formation of 5-methyltetrahydrofolate (5 …

Methylation is a crucially important ubiquitous biochemical process, which covalently adds
methyl groups to a variety of molecular targets. It is the key regulatory process that …

OBJECTIVE: To investigate associations between folate-metabolizing gene variations, folate
status, and unexplained female infertility. DESIGN: An association study. SETTING: Hospital …

The methylenetetrahydrofolate reductase (MTHFR) gene is one of the main regulatory
enzymes involved in folate metabolism, DNA synthesis and remethylation reactions. The …

The aim of this study was to investigate the association between MTHFR gene
polymorphisms and IVF outcomes in Brazilian women undergoing assisted reproduction …

Research question What is the association between homocysteine (Hcy) and
IVF/intracytoplasmic sperm injection (ICSI) outcomes, stratified by methylenetetrahydrofolate …

Mutant alleles with the 677C→ T and 1298A→ C polymorphisms of the MTHFR gene, and
consequent lower methylentetrahydrofolate reductase enzyme activity, have been related to …

MTHFR is an important enzyme in the metabolism of folic acid and is crucial for reproductive
function. Variation in the sequence of MTHFR has been implicated in subfertility, but …

Aim: Polymorphisms of genes connected to folate metabolism may alter the beneficial effect
of folic acid on the methyl group cycle. The most common variation is the 677C> T …