Simple Summary Multidrug-resistant bacterial infections, especially that caused by Gram-
negative bacteria, have posed serious health issues worldwide. Bacteria have different …

Efflux is an important mechanism in Gram-negative bacteria conferring multidrug resistance.
Inhibition of efflux is an encouraging strategy to restore the antibacterial activity of antibiotics …

The Escherichia coli AcrAB-TolC efflux pump is the archetype of the resistance nodulation
cell division (RND) exporters from Gram-negative bacteria. Overexpression of RND-type …

The rise in multidrug resistance (MDR) is one of the greatest threats to human health
worldwide. MDR in bacterial pathogens is a major challenge in healthcare, as bacterial …

The discovery of antibiotics represented a key milestone in the history of medicine. However,
with the rise of these life-saving drugs came the awareness that bacteria deploy defense …

The over-expression of multidrug efflux pumps belonging to the Resistance-Nodulation-
Division (RND) superfamily is one of the main causes of multidrug-resistance (MDR) in …

The increasing multi-drug resistance has become a major threat to the public health.
Overexpression of multidrug efflux pumps is one of the major mechanisms of drug resistance …

The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to
antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous …

In Gram-negative bacteria, efflux complexes, consisting of an inner-membrane pump, a
periplasmic adaptor protein and outer-membrane channel, provide an efficient means for the …

Efflux pumps of the resistance nodulation division (RND) superfamily, such as AcrB, make a
major contribution to multidrug resistance in Gram-negative bacteria. The development of …