Human cholangiocyte organoids are promising for regenerative medicine applications, such
as repair of damaged bile ducts. However, organoids are typically cultured in mouse tumor …

Organoid technology holds great promise for regenerative medicine. Recent studies show
feasibility for bile duct tissue repair in humans by successfully transplanting cholangiocyte …

The biliary tree is an essential component of transplantable human liver tissue. Despite
recent advances in liver tissue engineering, attempts at re-creating the intrahepatic biliary …

The treatment of common bile duct (CBD) disorders, such as biliary atresia or ischemic
strictures, is restricted by the lack of biliary tissue from healthy donors suitable for surgical …

Biliary disorders can lead to life‐threatening disease and are also a challenging
complication of liver transplantation. As there are limited treatment options, tissue …

Pediatric liver transplantation is often required as a consequence of biliary disorders
because of the lack of alternative treatments for repairing or replacing damaged bile ducts …

Despite recent advances in biomaterial science, there is yet no culture system that supports
long-term culture expansion of human adult hepatocytes, while preserving continued …

The integration of bile duct epithelial cells (cholangiocytes) in artificial liver culture systems
is important in order to generate more physiologically relevant liver models. Understanding …

Recent years have seen a proliferation of methods leading to successful organ
decellularization. In this experiment we examine the feasibility of a decellularized liver …

Cholangiopathies, such as primary sclerosing cholangitis, biliary atresia, and
cholangiocarcinoma, have limited experimental models. Not only cholangiocytes but also …