Enduring consequences of perinatal fentanyl exposure in mice

JB Alipio, AT Brockett, ME Fox, SS Tennyson… - Addiction …, 2021 - Wiley Online Library
Opioid use by pregnant women is an understudied consequence associated with the opioid
epidemic, resulting in a rise in the incidence of neonatal opioid withdrawal syndrome …

Developmental opioid exposures: neurobiological underpinnings, behavioral impacts, and policy implications

SS Goldfarb, GD Stanwood, HA Flynn… - Experimental …, 2020 - journals.sagepub.com
The devastating impact of opioid abuse and dependence on the individual, family, and
society are well known but extremely difficult to combat. During pregnancy, opioid drugs and …

Modeling prenatal opioid exposure in animals: current findings and future directions

EM Byrnes, FM Vassoler - Frontiers in neuroendocrinology, 2018 - Elsevier
The past decade has seen a drastic rise in the number of infants exposed to opioids in utero.
It is unclear what lasting effect this exposure may have on these children. Animal models of …

Maternal opioid exposure culminates in perturbed murine neurodevelopment and hyperactive phenotype in adolescence

CR Schlagal, TJ Dunn, P Xu, DE Felsing, CR Merritt… - Neuroscience, 2021 - Elsevier
Opioid use by women during pregnancy has risen dramatically since 2004, accompanied by
a striking increase in the prevalence of neonatal opioid withdrawal syndrome (NOWS) and …

[HTML][HTML] Early life opioid exposure and potential long-term effects

HJ Harder, AZ Murphy - Neurobiology of stress, 2019 - Elsevier
The long-term consequences of perinatal opioid exposure and subsequent development of
neonatal opioid withdrawal syndrome is largely unknown and likely dependent on a …

Prenatal opioid exposure and vulnerability to future substance use disorders in offspring

Y Abu, S Roy - Experimental neurology, 2021 - Elsevier
The heightened incidence of opioid use during pregnancy has resulted in unprecedented
rates of neonates prenatally exposed to opioids. Prenatal opioid exposure (POE) results in …

Perinatal fentanyl exposure leads to long-lasting impairments in somatosensory circuit function and behavior

JB Alipio, C Haga, ME Fox, K Arakawa… - Journal of …, 2021 - Soc Neuroscience
One consequence of the opioid epidemic are lasting neurodevelopmental sequelae
afflicting adolescents exposed to opioids in the womb. A translationally relevant and …

Perinatal oxycodone exposure causes long-term sex-dependent changes in weight trajectory and sensory processing in adult mice

E Minakova, MO Mikati, MK Madasu, SM Conway… - …, 2022 - Springer
Rationale In utero opioid exposure is associated with lower weight and a neonatal opioid
withdrawal syndrome (NOWS) at birth, along with longer-term adverse neurodevelopmental …

Perinatal morphine but not buprenorphine affects gestational and offspring neurobehavioral outcomes in mice

BL Smith, A Hassler, KR Lloyd, TM Reyes - Neurotoxicology, 2023 - Elsevier
Within the national opioid epidemic, there has been an increase in the number of infants
exposed to opioids in utero. Additionally, opioid agonist medications are the standard of …

Environmental enrichment mitigates the long-lasting sequelae of perinatal fentanyl exposure in mice

JB Alipio, LM Riggs, M Plank, A Keller - Journal of Neuroscience, 2022 - Soc Neuroscience
The opioid epidemic is a rapidly evolving societal issue driven, in part, by a surge in
synthetic opioid use. A rise in fentanyl use among pregnant women has led to a 40-fold …