Abstract Interleukin-33 (IL-33), a member of the IL-1 family, and its cognate receptor,
Interleukin-1 receptor like-1 (IL-1RL1 or ST2), are susceptibility genes for childhood asthma …

In complex disorders such as asthma and allergic disease, the goal for developing disease-
modifying biotherapeutics is to find a target that is a central instigator of immunologic activity …

Interleukin 33 (IL-33) is an alarmin cytokine from the IL-1 family. IL-33 is localized in the
nucleus and acts there as a gene regulator. Following injury, stress or cell death, it is …

Abstract Interleukin-33 (IL-33), a member of the IL-1 family, is an alarmin cytokine with
crucial roles in tissue homeostasis and repair, type 2 immunity, allergic and non-allergic …

The discovery of IL-33 as the ligand for the orphan Th2 associated receptor ST2 has
uncovered a whole range of different avenues for this pathway. Although the extracellular …

Asthma is a complex disease that results from the interaction between genetic predisposition
and environmental factors. Recently, genome-wide association studies have identified a …

Type 2 inflammation occurs in a large subgroup of asthmatics, and novel cytokine-directed
therapies are being developed to treat this population. In mouse models, interleukin-33 (IL …

Interleukin-33 (IL-33) is the 11th member of IL-1 cytokine family which includes IL-1 and IL-
18. Unlike IL-1β and IL-18, IL-33 is suggested to function as an alarmin that is released upon …

Abstract IL-33 is an IL-1-related cytokine which has been implicated in Th2-associated
biology and allergic diseases in humans and mice. IL-33 stimulates Th2 cells, mast cells …

Objective: Interleukin-33 is an IL-1 family cytokine which signals via its T1/ST2 receptor, and
acts as a key regulator of inflammation, notably the type-2 response implicated in asthma …