Highlights•Five percent of uterine and 20% of ovarian cancers are caused by germline
mutations.•There are recognised cancer predisposition syndromes causing gynaecological …

Genetics may not be at the forefront of every gynaecologist's mind when a woman presents
with gynaecological cancer. Staging, histological type and treatment options are much more …

Opinion statement Women with personal and family histories consistent with gynecologic
cancer-associated hereditary cancer susceptibility disorders should be referred for genetic …

Recognition of women and families at risk for inherited cancer syndromes is critical for both
management and prevention of gynecologic cancers as well as other syndromeassociated …

To determine the validity of observations suggesting a significant dichotomy of gynecologic
cancers determined by linkage to specific genetic defects associated with two major …

Women with germline mutations in the cancer susceptibility genes, BRCA1 or BRCA2,
associated with Hereditary Breast & Ovarian Cancer syndrome, have up to an 85% lifetime …

Approximately 10% of cancer deaths in women in Westernised countries are due to
gynaecological malignancy. Cancer results from the accumulation of multiple genetic …

Salient to the intent of personalized medicine, hereditary cancer syndromes present
significant opportunities in the treatment and prevention of some gynecologic cancers …

Abstract An estimated 2–5% of endometrial cancers and 15–20% of high-grade, non-
mucinous epithelial ovarian cancers have an underlying hereditary cause. Appropriate risk …

Hereditary gynecological cancers are caused by several inherited genes. Tumors that arise
in the female reproductive system, such as ovaries and the uterus, overlap with hereditary …