For most researchers, discovering new anticancer drugs to avoid the adverse effects of
current ones, to improve therapeutic benefits and to reduce resistance is essential. Because …

Introduction Epidermal growth factor receptor (EGFR) inhibition is an imperative therapeutic
approach targeting various types of cancer including colorectal, lung, breast, and pancreatic …

Novel quinoxaline derivatives (2a–d, 3, 4a, 4b and 5–15) have been synthesized via the
reaction of 4-methyl-3-oxo-3, 4-dihydroquinoxaline-2-carbohydrazide (1) with different …

Background: Due to the astonishing properties of ferrocene and its derivatives, it has a
broad application in diverse areas. Numerous ferrocene derivatives demonstrated anti …

Over the last few decades, a growing body of studies addressed the anticancer activity of
NSAIDs, particularly selective COX-2 inhibitors. However, their exact molecular mechanism …

Cyclooxygenases (COXs) play a pivotal role in inflammation, a complex phenomenon
required in human defense, but also involved in the emergence of insidious human …

Cancer is considered as a challenging deathly disease and discovering or synthesis of new
cytotoxic agents is a worldwide attempt. In this study, a group of recently synthesized …

A new series of chalcones (1− 9) possessing an SO2CH3 COX‐2 pharmacophore at the
para position of the C‐1 phenyl ring was synthesized via the Claisen–Schmidt condensation …

A new series of NSAID thioesters were synthesized and evaluated for their in vitro antitumor
effects against a panel of four human tumor cell lines, namely: HepG2, MCF-7, HCT-116 and …

Novel differently substituted pyrazole derivatives were designed, synthesized and evaluated
for their anticancer activity. All compounds selectively inhibited COX-2 enzyme (IC 50 …