Dyspnea, exercise intolerance, and activity restriction are already apparent in mild chronic
obstructive pulmonary disease (COPD). However, patients may not seek medical help until …

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality
worldwide and, although it is a preventable and treatable disease, it often remains …

Background and objective The combination of both reduced resting diffusing capacity of the
lung for carbon monoxide (DLCO) and ventilatory efficiency (increased ventilatory …

Patients with chronic obstructive pulmonary disease (COPD) are often caught in a
downward spiral that progresses from expiratory flow limitation to poor quality of life and …

Background: Exercise intolerance is a hallmark of chronic obstructive pulmonary disease
(COPD) and forced expiratory volume in one second (FEV1) is the traditional metric used to …

Dyspnea is the most frequent complaint limiting physical activities in patients with COPD and
decreased exercise capacity is at the center of functional limitation of these patients. This …

Decreased exercise capacity is a prominent symptom leading to progressive disablement in
chronic obstructive pulmonary disease (COPD). Exercise capacity is frequently measured by …

Impaired exercise tolerance is a prominent feature of chronic obstructive pulmonary disease
(COPD). 46, 59 Patients with COPD demonstrate widely variable exercise capacities …

BACKGROUND: Patients with COPD have reduced exercise tolerance associated with
dyspnea. This exercise intolerance is primarily due to impaired ventilatory mechanics, but it …

Physical activity is defined by the World Health Organization as “any force exerted by the
skeletal muscles that results in energy expenditure above resting level”[1]. In this very broad …