Asthma is an allergic airway inflammatory disease characterized by type 2 immune
responses. Growing evidence suggests an association between allergic airways and …

Asthma is described as a chronic inflammatory disorder of the conducting airways. It is
characterized by reversible airway obstruction, eosinophil and Th2 infiltration, airway hyper …

Background Recent studies have suggested that upper airway inflammation has a strong
impact on lower airway diseases. The purpose of this study was to assess whether nasal …

Background Asthma is a chronic respiratory disease with marked clinical and
pathophysiological heterogeneity. Specific pathways are thought to be involved in the …

House dust mite (HDM) challenge is commonly used in murine models of allergic asthma for
preclinical pathophysiological studies. However, few studies define objective readouts or …

Abstract Background/Aims: Epidemiological data show that there is an important relationship
between respiratory and intestinal diseases. To improve our understanding on the …

Asthma is a chronic inflammatory disease of the airways, involving recurrent episodes of
airway obstruction and wheezing. A common pathological feature in asthma is the presence …

Asthma is a common respiratory disease affecting∼ 300 million people worldwide. Airway
inflammation is thought to contribute to asthma pathogenesis, but the direct relationship …

Rationale Non-allergic asthma is driven by multiple endotypes of which neutrophilic and
pauci-granulocytic asthma have been best established. However, it is still puzzling what …

Allergic rhinitis, chronic rhinosinusitis, and asthma are highly prevalent, multifactorial chronic
airway diseases. Several environmental and genetic factors affect airway epithelial …