MACHETE identifies interferon-encompassing chromosome 9p21. 3 deletions as mediators of immune evasion and metastasis
The most prominent homozygous deletions in cancer affect chromosome 9p21. 3 and
eliminate CDKN2A/B tumor suppressors, disabling a cell-intrinsic barrier to tumorigenesis …
eliminate CDKN2A/B tumor suppressors, disabling a cell-intrinsic barrier to tumorigenesis …
Cancer cells resistant to immune checkpoint blockade acquire interferon-associated epigenetic memory to sustain T cell dysfunction
Prolonged interferon (IFN) signaling in cancer cells can promote resistance to immune
checkpoint blockade (ICB). How cancer cells retain effects of prolonged IFN stimulation to …
checkpoint blockade (ICB). How cancer cells retain effects of prolonged IFN stimulation to …
Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion
Resistance to immune checkpoint inhibitors (ICIs) is a key challenge in cancer therapy. To
elucidate underlying mechanisms, we developed Perturb-CITE-sequencing (Perturb-CITE …
elucidate underlying mechanisms, we developed Perturb-CITE-sequencing (Perturb-CITE …
Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice
AH Lund, G Turner, A Trubetskoy, E Verhoeven… - Nature …, 2002 - nature.com
We have used large-scale insertional mutagenesis to identify functional landmarks relevant
to cancer in the recently completed mouse genome sequence. We infected Cdkn2a−/− mice …
to cancer in the recently completed mouse genome sequence. We infected Cdkn2a−/− mice …
Epigenetic disruption of interferon-γ response through silencing the tumor suppressor interferon regulatory factor 8 in nasopharyngeal, esophageal and multiple other …
KY Lee, H Geng, KM Ng, J Yu, A Van Hasselt, Y Cao… - Oncogene, 2008 - nature.com
Abstract 16q24 is frequently deleted in multiple tumors including cancers of nasopharynx,
esophagus, breast, prostate and liver. By array comparative genomic hybridization (aCGH) …
esophagus, breast, prostate and liver. By array comparative genomic hybridization (aCGH) …
Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape
Breast cancer metastasis is a key determinant of long-term patient survival. By comparing
the transcriptomes of primary and metastatic tumor cells in a mouse model of spontaneous …
the transcriptomes of primary and metastatic tumor cells in a mouse model of spontaneous …
Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model
Down syndrome (DS), the genetic condition caused by trisomy 21, is characterized by
variable cognitive impairment, immune dysregulation, dysmorphogenesis and increased …
variable cognitive impairment, immune dysregulation, dysmorphogenesis and increased …
Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss
H Liu, J Golji, LK Brodeur, FS Chung, JT Chen… - Nature medicine, 2019 - nature.com
Interferons (IFNs) are cytokines that play a critical role in limiting infectious and malignant
diseases,,–. Emerging data suggest that the strength and duration of IFN signaling can …
diseases,,–. Emerging data suggest that the strength and duration of IFN signaling can …
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
Loss of heterozygosity on chromosome 9p21 is one of the most frequent genetic alterations
identified in human cancer. The rate of point mutations of p16, a candidate suppressor gene …
identified in human cancer. The rate of point mutations of p16, a candidate suppressor gene …
ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity
JA Moral, J Leung, LA Rojas, J Ruan, J Zhao, Z Sethna… - Nature, 2020 - nature.com
Group 2 innate lymphoid cells (ILC2s) regulate inflammation and immunity in mammalian
tissues,. Although ILC2s are found in cancers of these tissues, their roles in cancer immunity …
tissues,. Although ILC2s are found in cancers of these tissues, their roles in cancer immunity …