BMP6 regulates proliferation and apoptosis of human Sertoli cells via Smad2/3 and Cyclin D1 pathway and DACH1 and TFAP2A activation

H Wang, Q Yuan, M Sun, M Niu, L Wen, H Fu, F Zhou… - Scientific reports, 2017 - nature.com
Sertoli cells are essential for regulating normal spermatogenesis. However, the mechanisms
underlying human Sertoli cell development remain largely elusive. Here we examined the …

[HTML][HTML] BMP4 promotes human Sertoli cell proliferation via Smad1/5 and ID2/3 pathway and its abnormality is associated with azoospermia

Y Hai, M Sun, M Niu, Q Yuan, Y Guo… - Discovery …, 2015 - discoverymedicine.com
Sertoli cell plays critical roles in regulating testis development and spermatogenesis. Any
change in the number or biological functions of Sertoli cells can affect the normal formation …

BMP8A sustains spermatogenesis by activating both SMAD1/5/8 and SMAD2/3 in spermatogonia

FJ Wu, TY Lin, LY Sung, WF Chang, PC Wu… - Science signaling, 2017 - science.org
Mutation in either of the genes encoding bone morphogenetic protein (BMP) 8A or 8B
(Bmp8a or Bmp8b) causes postnatal depletion of spermatogonia in mice. We found that …

BMP4/Smad signaling pathway induces the differentiation of mouse spermatogonial stem cells via upregulation of Sohlh2

Y Li, Y Zhang, X Zhang, J Sun, J Hao - The Anatomical Record, 2014 - Wiley Online Library
Spermatogonial stem cells (SSCs) capable of self‐renewal and differentiation are the
foundation for spermatogenesis. Although several factors that govern these processes have …

Human BMP8A suppresses luteinization of rat granulosa cells via the SMAD1/5/8 pathway

FJ Wu, YW Wang, CW Luo - Reproduction, 2020 - rep.bioscientifica.com
Bone morphogenetic proteins (BMPs) are known to play an indispensable role in preventing
the precocious luteinization of granulosa cells within growing ovarian follicles. In this study …

BMP9 maintains the phenotype of HTR-8/Svneo trophoblast cells by activating the SDF1/CXCR4 pathway

X Yang, L Ren, X Chen, Y Pang, B Jia, J Sun… - BMC Molecular and Cell …, 2023 - Springer
Background Bone morphogenetic protein 9 (BMP9) has been shown to regulate processes
such as angiogenesis, endothelial dysfunction, and tumorigenesis. However, the role of …

Bmp2 regulates Serpinb6b expression via cAMP/PKA/Wnt4 pathway during uterine decidualization

HF Yu, LW Zheng, ZQ Yang, YS Wang… - Journal of Cellular …, 2020 - Wiley Online Library
Serpinb6b is a novel member of Serpinb family and found in germ and somatic cells of
mouse gonads, but its physiological function in uterine decidualization remains unclear. The …

ALK3-SMAD1/5 signaling mediates the BMP2-induced decrease in PGE2 production in human endometrial stromal cells and decidual stromal cells

Y Zhang, H Zhu, HM Chang… - Frontiers in Cell and …, 2020 - frontiersin.org
BMP2 is a critical factor that is involved in the processes of embryo implantation and uterine
decidualization. The expression of cyclooxygenase (COX) and subsequent prostaglandin …

[HTML][HTML] Expression of BMP7 in cervical cancer and inhibition of epithelial‑mesenchymal transition by BMP7 knockdown in HeLa cells

R Sun, H Guan, W Liu, J Liang… - … Journal of Molecular …, 2020 - spandidos-publications.com
The aim of the present study was to investigate the expression of bone morphogenetic
protein 7 (BMP7) in cervical cancer tissues, the effect of BMP7 on the proliferation, migration …

The BMP4-Smad signaling pathway regulates hyperandrogenism development in a female mouse model

Y Liu, SY Du, M Ding, X Dou, FF Zhang, ZY Wu… - Journal of Biological …, 2017 - ASBMB
Polycystic ovary syndrome is a common endocrine disorder and a major cause of
anovulatory sterility in women at reproductive age. Most patients with polycystic ovary …