α‐Asarone attenuates chronic sciatica by inhibiting peripheral sensitization and promoting neural repair

D Zhang, X Li, B Jing, Z Chen, H Shi… - Phytotherapy …, 2023 - Wiley Online Library
This study explored the therapeutic effect of α‐asarone on chronic sciatica. Thirty‐two
Sprague–Dawley (SD) rats were divided into four groups: the sham group, chronic …

Oral administration of α-Asarone promotes functional recovery in rats with spinal cord injury

MJ Jo, H Kumar, HP Joshi, H Choi, WK Ko… - Frontiers in …, 2018 - frontiersin.org
α-asarone, a bioactive compound found in Acorus plant species, has been shown to exhibit
neuroprotective, anti-oxidative, anti-inflammatory, and cognitive-enhancing effects …

Pro-neurogenic effect of β-asarone on RSC96 Schwann cells in vitro

F Xu, H Wu, K Zhang, P Lv, L Zheng, J Zhao - In Vitro Cellular & …, 2016 - Springer
Nerve regeneration is a challenge for the therapy of peripheral nerve injury. β-Asarone, a
major compound extracted from Acorus tatarinowii Schott rhizome, has been traditionally …

Effect of hydroalcoholic extract of Acorus calamus on tibial and sural nerve transection-induced painful neuropathy in rats

A Muthuraman, N Singh, AS Jaggi - Journal of natural medicines, 2011 - Springer
This study was designed to investigate the therapeutic potential of hydroalcoholic extracts of
Acorus calamus (AC) in tibial and sural nerve transection (TST)-induced neuropathic pain in …

Therapeutic effect of paeoniflorin on chronic constriction injury of the sciatic nerve via the inhibition of Schwann cell apoptosis

D Zhang, S Chang, X Li, H Shi, B Jing… - Phytotherapy …, 2022 - Wiley Online Library
Therapeutic drugs of chronic neuralgia have a high risk of addiction, making it crucial to
identify novel drugs for chronic neuralgia. This study aimed to explore the therapeutic effect …

Anti-allodynic effect of intrathecal processed Aconitum jaluense is associated with the inhibition of microglial activation and P2X7 receptor expression in spinal cord

J Yang, KS Park, JJ Yoon, HB Bae, MH Yoon… - … and alternative medicine, 2016 - Springer
Background For their analgesic and anti-arthritic effects, Aconitum species have been used
in folk medicine in some East Asian countries. Although their analgesic effect is attributed to …

Paeoniflorin and albiflorin attenuate neuropathic pain via MAPK pathway in chronic constriction injury rats

J Zhou, L Wang, J Wang, C Wang… - Evidence‐Based …, 2016 - Wiley Online Library
Neuropathic pain remains as the most frequent cause of suffering and disability around the
world. The isomers paeoniflorin (PF) and albiflorin (AF) are major constituents extracted from …

Attenuation of neuropathic pain by saikosaponin a in a rat model of chronic constriction injury

X Zhou, H Cheng, D Xu, Q Yin, L Cheng, L Wang… - Neurochemical …, 2014 - Springer
Despite immense advances in the treatment strategies, the effective treatment of patients
suffering from neuropathic pain remains challenging. Saikosaponin a possesses anti …

Neuroprotective effect of saponin rich extract of Acorus calamus L. in rat model of chronic constriction injury (CCI) of sciatic nerve-induced neuropathic pain

A Muthuraman, N Singh - Journal of ethnopharmacology, 2012 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Traditionally, Acorus calamus has been used
for the treatment and management of headache, migraine, body ache and severe …

Therapeutic Effect of Tetrapanax papyriferus and Hederagenin on Chronic Neuropathic Pain of Chronic Constriction Injury of Sciatic Nerve Rats Based on KEGG …

D Zhang, J Sun, B Yang, S Ma… - Evidence‐Based …, 2020 - Wiley Online Library
Background. Hederagenin is one of the main components of Tetrapanax papyriferus, and
Tetrapanax papyriferus is one of the ingredients of Danggui Sini decoction. To explore …