Host–microbiota interactions in rheumatoid arthritis

Y Maeda, K Takeda - Experimental & Molecular Medicine, 2019 - nature.com
The gut microbiota has been proposed to be an important environmental factor in the
development of rheumatoid arthritis (RA). Here, we review a growing body of evidence from …

Role of gut microbiota in rheumatoid arthritis

Y Maeda, K Takeda - Journal of clinical medicine, 2017 - mdpi.com
Rheumatoid arthritis (RA) is a systemic autoimmune disease, caused by both genetic and
environmental factors. Recently, investigators have focused on the gut microbiota, which is …

Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine

Y Maeda, T Kurakawa, E Umemoto… - Arthritis & …, 2016 - Wiley Online Library
Objective The intestinal microbiota is involved in the pathogenesis of arthritis. Altered
microbiota composition has been demonstrated in patients with rheumatoid arthritis (RA) …

Intestinal dysbiosis and rheumatoid arthritis: a link between gut microbiota and the pathogenesis of rheumatoid arthritis

G Horta-Baas, MS Romero-Figueroa… - Journal of …, 2017 - Wiley Online Library
Characterization and understanding of gut microbiota has recently increased representing a
wide research field, especially in autoimmune diseases. Gut microbiota is the major source …

Gut microbiota and rheumatoid arthritis: From pathogenesis to novel therapeutic opportunities

T Zhao, Y Wei, Y Zhu, Z Xie, Q Hai, Z Li… - Frontiers in …, 2022 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects the joints.
Microbial infection is considered a crucial inducer of RA. Alterations in the composition of …

Troublesome friends within us: the role of gut microbiota on rheumatoid arthritis etiopathogenesis and its clinical and therapeutic relevance

Z Reyes-Castillo, E Valdés-Miramontes… - Clinical and …, 2021 - Springer
The role of gut microbiota on immune regulation and the development of autoimmune
diseases such as rheumatoid arthritis (RA) is an emerging research topic. Multiple studies …

Alteration of the intestinal microbiome characterizes preclinical inflammatory arthritis in mice and its modulation attenuates established arthritis

R Rogier, H Evans-Marin, J Manasson… - Scientific reports, 2017 - nature.com
Perturbations of the intestinal microbiome have been observed in patients with new-onset
and chronic autoimmune inflammatory arthritis. However, it is currently unknown whether …

Interactions between gut microbiota and immunomodulatory cells in rheumatoid arthritis

H Xu, H Zhao, D Fan, M Liu, J Cao, Y Xia… - Mediators of …, 2020 - Wiley Online Library
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases caused by
abnormal immune activation and immune tolerance. Immunomodulatory cells (ICs) play a …

Infectious agents and inflammation: the role of microbiota in autoimmune arthritis

A Picchianti-Diamanti, MM Rosado… - Frontiers in …, 2018 - frontiersin.org
In higher vertebrates, mucosal sites at the border between the internal and external
environments, directly interact with bacteria, viruses, and fungi. Through co-evolution, hosts …

Oral–gut microbiota and arthritis: is there an evidence-based axis?

L Drago, GV Zuccotti, CL Romanò, K Goswami… - Journal of clinical …, 2019 - mdpi.com
The gut microbiome appears to be a significant contributor to musculoskeletal health and
disease. Recently, it has been found that oral microbiota are involved in arthritis …