AMP-activated protein kinase: the current landscape for drug development

GR Steinberg, D Carling - Nature reviews Drug discovery, 2019 - nature.com
Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

[HTML][HTML] Dissecting the role of AMP-activated protein kinase in human diseases

J Li, L Zhong, F Wang, H Zhu - Acta Pharmaceutica Sinica B, 2017 - Elsevier
AMP-activated protein kinase (AMPK), known as a sensor and a master of cellular energy
balance, integrates various regulatory signals including anabolic and catabolic metabolic …

Promise and challenges for direct small molecule AMPK activators

S Olivier, M Foretz, B Viollet - Biochemical pharmacology, 2018 - Elsevier
AMP-activated protein kinase (AMPK) is an evolutionary conserved and ubiquitously
expressed serine/threonine kinase playing a central role in the coordination of energy …

Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662

S Ducommun, RJ Ford, L Bultot… - American Journal …, 2014 - journals.physiology.org
AMP-activated protein kinase (AMPK) is a key cellular energy sensor and regulator of
metabolic homeostasis. Activation of AMPK provides beneficial outcomes in fighting against …

AMPK: a metabolic gauge regulating whole-body energy homeostasis

R Lage, C Diéguez, A Vidal-Puig, M López - Trends in molecular medicine, 2008 - cell.com
AMP-activated protein kinase (AMPK) is the downstream component of a kinase cascade
that acts as a gauge of cellular energy levels. Over the last few years, accumulating …

AMP-activated protein kinase: also regulated by ADP?

DG Hardie, D Carling, SJ Gamblin - Trends in biochemical sciences, 2011 - cell.com
AMPK is a ubiquitous sensor of cellular energy status in eukaryotic cells. It is activated by
stresses causing ATP depletion and, once activated, maintains energy homeostasis by …

[HTML][HTML] AMP-activated protein kinase–not just an energy sensor

DG Hardie, SC Lin - F1000Research, 2017 - ncbi.nlm.nih.gov
Orthologues of AMP-activated protein kinase (AMPK) occur in essentially all eukaryotes as
heterotrimeric complexes comprising catalytic α subunits and regulatory β and γ subunits …

Effect of different γ-subunit isoforms on the regulation of AMPK

R Willows, N Navaratnam, A Lima, J Read… - Biochemical …, 2017 - portlandpress.com
AMP-activated protein kinase (AMPK) plays a key role in integrating metabolic pathways in
response to energy demand. AMPK activation results in a wide range of downstream …

AMPK in health and disease

GR Steinberg, BE Kemp - Physiological reviews, 2009 - journals.physiology.org
The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …

AMPK: an emerging drug target for diabetes and the metabolic syndrome

BB Zhang, G Zhou, C Li - Cell metabolism, 2009 - cell.com
Adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) is a key player in
regulating energy metabolism, placing it at the center stage in studies of diabetes and …