[HTML][HTML] AMP-activated protein kinase: the current landscape for drug development
GR Steinberg, D Carling - Nature reviews Drug discovery, 2019 - nature.com
Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …
homeostasis, many exciting insights into its structure, regulation and physiological roles …
[HTML][HTML] Dissecting the role of AMP-activated protein kinase in human diseases
J Li, L Zhong, F Wang, H Zhu - Acta Pharmaceutica Sinica B, 2017 - Elsevier
AMP-activated protein kinase (AMPK), known as a sensor and a master of cellular energy
balance, integrates various regulatory signals including anabolic and catabolic metabolic …
balance, integrates various regulatory signals including anabolic and catabolic metabolic …
Promise and challenges for direct small molecule AMPK activators
S Olivier, M Foretz, B Viollet - Biochemical pharmacology, 2018 - Elsevier
AMP-activated protein kinase (AMPK) is an evolutionary conserved and ubiquitously
expressed serine/threonine kinase playing a central role in the coordination of energy …
expressed serine/threonine kinase playing a central role in the coordination of energy …
Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662
S Ducommun, RJ Ford, L Bultot… - American Journal …, 2014 - journals.physiology.org
AMP-activated protein kinase (AMPK) is a key cellular energy sensor and regulator of
metabolic homeostasis. Activation of AMPK provides beneficial outcomes in fighting against …
metabolic homeostasis. Activation of AMPK provides beneficial outcomes in fighting against …
AMPK: a metabolic gauge regulating whole-body energy homeostasis
AMP-activated protein kinase (AMPK) is the downstream component of a kinase cascade
that acts as a gauge of cellular energy levels. Over the last few years, accumulating …
that acts as a gauge of cellular energy levels. Over the last few years, accumulating …
AMP-activated protein kinase: also regulated by ADP?
AMPK is a ubiquitous sensor of cellular energy status in eukaryotic cells. It is activated by
stresses causing ATP depletion and, once activated, maintains energy homeostasis by …
stresses causing ATP depletion and, once activated, maintains energy homeostasis by …
AMPK in health and disease
GR Steinberg, BE Kemp - Physiological reviews, 2009 - journals.physiology.org
The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …
[HTML][HTML] AMP-activated protein kinase–not just an energy sensor
Orthologues of AMP-activated protein kinase (AMPK) occur in essentially all eukaryotes as
heterotrimeric complexes comprising catalytic α subunits and regulatory β and γ subunits …
heterotrimeric complexes comprising catalytic α subunits and regulatory β and γ subunits …
[HTML][HTML] AMPK: an emerging drug target for diabetes and the metabolic syndrome
BB Zhang, G Zhou, C Li - Cell metabolism, 2009 - cell.com
Adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) is a key player in
regulating energy metabolism, placing it at the center stage in studies of diabetes and …
regulating energy metabolism, placing it at the center stage in studies of diabetes and …
AMPK activators–potential therapeutics for metabolic and other diseases
G Zhou, IK Sebhat, BB Zhang - Acta physiologica, 2009 - Wiley Online Library
AMP‐activated protein kinase (AMPK)‐mediated cellular metabolic responses to tissue‐
specific and whole‐body stimuli play a vital role in the control of energy homeostasis. As a …
specific and whole‐body stimuli play a vital role in the control of energy homeostasis. As a …