[HTML][HTML] Celastrol as an emerging anticancer agent: Current status, challenges and therapeutic strategies
C Wang, S Dai, X Zhao, Y Zhang, L Gong, K Fu… - Biomedicine & …, 2023 - Elsevier
Celastrol is a pentacyclic triterpenoid extracted from the traditional Chinese medicine
Tripterygium wilfordii Hook F., which has multiple pharmacological activities. In particular …
Tripterygium wilfordii Hook F., which has multiple pharmacological activities. In particular …
Celastrol in cancer therapy: Recent developments, challenges and prospects
Cancer is one of the world's biggest healthcare burdens and despite the current
advancements made in treatment plans, the outcomes for oncology patients have yet to …
advancements made in treatment plans, the outcomes for oncology patients have yet to …
[HTML][HTML] Celastrol: a review of useful strategies overcoming its limitation in anticancer application
J Shi, J Li, Z Xu, L Chen, R Luo, C Zhang… - Frontiers in …, 2020 - frontiersin.org
Celastrol, a natural bioactive ingredient derived from Tripterygium wilfordii Hook F, exhibits
significant broad-spectrum anticancer activities for the treatment of a variety of cancers …
significant broad-spectrum anticancer activities for the treatment of a variety of cancers …
Molecular targets of celastrol in cancer: Recent trends and advancements
Despite the advancement in the well-equipped and sophisticated laboratories and facilities,
cancer remains to be a major cause of death worldwide. Consequently, further investigation …
cancer remains to be a major cause of death worldwide. Consequently, further investigation …
[HTML][HTML] Celastrol Inhibits the Growth of Ovarian Cancer Cells in vitro and in vivo
LN Xu, N Zhao, JY Chen, PP Ye, XW Nan… - Frontiers in …, 2019 - frontiersin.org
Celastrol is a natural triterpene isolated from the Chinese plant Thunder God Vine with
potent antitumor activity. However, the effect of celastrol on the growth of ovarian cancer …
potent antitumor activity. However, the effect of celastrol on the growth of ovarian cancer …
Celastrol as a pentacyclic triterpenoid with chemopreventive properties
Celastrol is a highly investigated anticancer moiety. It is a pentacyclic triterpenoid, isolated
several decades ago with promising role in chemoprevention. Celastrol has been found to …
several decades ago with promising role in chemoprevention. Celastrol has been found to …
Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways
Celastrol, a plant triterpene has attracted great interest recently, especially for its potential
anti-inflammatory and anti-cancer activities. In the present report, we investigated the effect …
anti-inflammatory and anti-cancer activities. In the present report, we investigated the effect …
[HTML][HTML] Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells
X Liu, P Zhao, X Wang, L Wang, Y Zhu, Y Song… - Journal of Experimental …, 2019 - Springer
Background Celastrol, a triterpene compound derived from the traditional Chinese medicine
Tripterygium wilfordii, has been reported to possess potential antitumor activity towards …
Tripterygium wilfordii, has been reported to possess potential antitumor activity towards …
[HTML][HTML] Potential medicinal value of celastrol and its synthesized analogues for central nervous system diseases
X Bai, RJ Fu, S Zhang, SJ Yue, YY Chen, DQ Xu… - Biomedicine & …, 2021 - Elsevier
The central nervous system (CNS) is a vital part of the human nervous system, and the
incidence of CNS disease is increasing year by year, which has become a major public …
incidence of CNS disease is increasing year by year, which has become a major public …
Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer
R Kannaiyan, MK Shanmugam, G Sethi - Cancer letters, 2011 - Elsevier
Identification of active constituents and their molecular targets from traditional medicine is an
enormous opportunity for modern pharmacology. Celastrol is one such compound that was …
enormous opportunity for modern pharmacology. Celastrol is one such compound that was …