[HTML][HTML] Celastrol as an emerging anticancer agent: Current status, challenges and therapeutic strategies

C Wang, S Dai, X Zhao, Y Zhang, L Gong, K Fu… - Biomedicine & …, 2023 - Elsevier
Celastrol is a pentacyclic triterpenoid extracted from the traditional Chinese medicine
Tripterygium wilfordii Hook F., which has multiple pharmacological activities. In particular …

Celastrol in cancer therapy: Recent developments, challenges and prospects

HY Lim, PS Ong, L Wang, A Goel, L Ding, ALA Wong… - Cancer Letters, 2021 - Elsevier
Cancer is one of the world's biggest healthcare burdens and despite the current
advancements made in treatment plans, the outcomes for oncology patients have yet to …

[HTML][HTML] Celastrol: a review of useful strategies overcoming its limitation in anticancer application

J Shi, J Li, Z Xu, L Chen, R Luo, C Zhang… - Frontiers in …, 2020 - frontiersin.org
Celastrol, a natural bioactive ingredient derived from Tripterygium wilfordii Hook F, exhibits
significant broad-spectrum anticancer activities for the treatment of a variety of cancers …

Molecular targets of celastrol in cancer: Recent trends and advancements

D Kashyap, A Sharma, HS Tuli, K Sak… - Critical Reviews in …, 2018 - Elsevier
Despite the advancement in the well-equipped and sophisticated laboratories and facilities,
cancer remains to be a major cause of death worldwide. Consequently, further investigation …

[HTML][HTML] Celastrol Inhibits the Growth of Ovarian Cancer Cells in vitro and in vivo

LN Xu, N Zhao, JY Chen, PP Ye, XW Nan… - Frontiers in …, 2019 - frontiersin.org
Celastrol is a natural triterpene isolated from the Chinese plant Thunder God Vine with
potent antitumor activity. However, the effect of celastrol on the growth of ovarian cancer …

Celastrol as a pentacyclic triterpenoid with chemopreventive properties

P Yadav, V Jaswal, A Sharma, D Kashyap… - Pharmaceutical …, 2018 - Taylor & Francis
Celastrol is a highly investigated anticancer moiety. It is a pentacyclic triterpenoid, isolated
several decades ago with promising role in chemoprevention. Celastrol has been found to …

Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways

R Kannaiyan, KA Manu, L Chen, F Li, P Rajendran… - Apoptosis, 2011 - Springer
Celastrol, a plant triterpene has attracted great interest recently, especially for its potential
anti-inflammatory and anti-cancer activities. In the present report, we investigated the effect …

[HTML][HTML] Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells

X Liu, P Zhao, X Wang, L Wang, Y Zhu, Y Song… - Journal of Experimental …, 2019 - Springer
Background Celastrol, a triterpene compound derived from the traditional Chinese medicine
Tripterygium wilfordii, has been reported to possess potential antitumor activity towards …

[HTML][HTML] Potential medicinal value of celastrol and its synthesized analogues for central nervous system diseases

X Bai, RJ Fu, S Zhang, SJ Yue, YY Chen, DQ Xu… - Biomedicine & …, 2021 - Elsevier
The central nervous system (CNS) is a vital part of the human nervous system, and the
incidence of CNS disease is increasing year by year, which has become a major public …

Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer

R Kannaiyan, MK Shanmugam, G Sethi - Cancer letters, 2011 - Elsevier
Identification of active constituents and their molecular targets from traditional medicine is an
enormous opportunity for modern pharmacology. Celastrol is one such compound that was …