β-Adrenoceptor blocking agents as partial agonists in isolated heart muscle: Dissociation of stimulation and blockade

AJ Kaumann, JR Blinks - Naunyn-Schmiedeberg's archives of …, 1980 - Springer
The cardiac stimulant actions of nine β-adrenoceptor blocking agents were examined in
kitten papillary muscles and in isolated atria of kittens and guinea pigs to determine to what …

Stimulant and depressant effects ofβ-adrenoceptor blocking agents on isolated heart muscle: A positive inotropic effect not mediated through adrenoceptors

AJ Kaumann, JR Blinks - Naunyn-Schmiedeberg's Archives of …, 1980 - Springer
The chronotropic and inotropic effects of fourteen β-adrenoceptor blocking agents were
studied in vitro on preparations of isolated heart muscle from kittens and guinea pigs. Most …

Comparative assessment ofβ-adrenoceptor blocking agents as simple competitive antagonists in isolated heart muscle: Similarity of inotropic and chronotropic …

AJ Kaumann, TK McInerny, DP Gilmour… - Naunyn-Schmiedeberg's …, 1980 - Springer
The pattern of antagonism between isoproterenol and various β-adrenoceptor blocking
agents was explored in spontaneously beating right atria and in driven left atrial strips from …

The actions of a new β-adrenoceptor blocking drug, ICI 66082, on the rabbit papillary muscle and on the dog heart

JD Harry, MF Knapp, RJ Linden - British Journal of Pharmacology, 1974 - ncbi.nlm.nih.gov
Abstract 1 The actions of 4-(2-hydroxy-3-isopropylaminopropoxy) phenyl acetamide (ICI
66082), a new β-adrenoceptor blocking drug, on the twitch response of the isolated papillary …

Direct labelling of myocardial β 1-adrenoceptors: Comparison of binding affinity of 3H-(−)-bisoprolol with its blocking potency

AJ Kaumann, H Lemoine - Naunyn-Schmiedeberg's archives of …, 1985 - Springer
A radioligand that selectively labels β 1-adrenoceptors, 3 H-(−)-bisoprolol (3 H-BIS), is
introduced. The binding properties of 3 H-BIS to membrane particles of kitten heart are …

The effect of “selective” β-adrenoceptor blocking drugs on the myocardial circulation

JR Parratt, RM Wadsworth - British Journal of Pharmacology, 1970 - ncbi.nlm.nih.gov
drugs on the myocardialcirculation Page 1 Br. J. Pharmac. (1970), 39, 296-308. The effect of
"selective" 3-adrenoceptor blocking drugs on the myocardialcirculation JR PARRATT AND …

Central actions of β‐adrenoceptor blocking drugs in man

L Patel, P Turner - Medicinal Research Reviews, 1981 - Wiley Online Library
The classification of adrenoceptors into two major groups a and j?'and of j?-adrenoceptors
into two subgroups j?. and p.'depended mainly on the comparison of relative order of …

[引用][C] EVALUATION OF THE CARDIAC EFFECTS OF SEVERAL BETA ADRENERGIC BLOCKING AGENTS

JR Blinks - Annals of the New York Academy of Sciences, 1967 - Wiley Online Library
Methods Experiments were performed on isolated guinea-pig atria and on the atria and
papillary muscles of kittens. Chronotropic effects were determined on the spontaneously …

Heart β-adrenoceptors

AJ Kaumann, L Birnbaumer, R Wittmann - Receptors and hormone action, 1978 - Elsevier
Publisher Summary This chapter discusses heart β-adrenoceptors, wherein adrenoceptors
have been classified by comparing relative potencies of agonists and with the help of …

[PDF][PDF] Inotropic and metabolic effects of three beta-adrenergic receptor blocking drugs on isolated rabbit left atria

JV Levy, V Richards - Journal of Pharmacology and Experimental …, 1965 - Citeseer
METHODS. All experiments were performed on isolated left atrial preparations obtained
from white New Zealand female rabbits weighing 2.0 to 2.6 kg. Contraction studies. Inotropic …