In mammals, the rate of somatic growth is rapid in early postnatal life but then slows with
age, approaching zero as the animal approaches adult body size. To investigate the …

Abstract Background Conlon and Raff propose that mammalian cells grow linearly during
the division cycle. According to Conlon and Raff, cells growing linearly do not need a size …

For over a century it has been generally recognized that aging begins when growth ceases,
that those animals which grow as long as they live may live as long as they grow. The …

How is the size of an organism or organ determined? activated to trigger the different phases
of the cell cycle Why, for example, are we larger than mice? Although at the right time and in …

Growth in its simplest form is increase in size. The growth of the body is the sum of the
increases in size of its organs and tissues. These increases, in turn, may occur in three …

Evidence is presented that rat embryo cultures undergo an in vitro aging process similar to
that described for mouse embryo, chick, and human cell cultures. Measurements of the …

In mammals, after a period of growth inhibition, body growth often does not just return to a
normal rate but actually exceeds the normal rate, resulting in catch-up growth. Recent …

A long-standing question in biology is whether there is an intrinsic mechanism for
coordinating growth and the cell cycle in metazoan cells. We examined cell size distributions …

The proportion of hepatocytic nuclei that incorporates tritiated thymidine after pulse labeling
or that is in mitosis falls rapidly after birth (Fig. 1). After a short lag, cellular proliferation then …

Growth of mice from 2 lines selected for low and high body weight at 21 days of age
(weaning) for 90 generations was compared. Body composition of 10 males and 10 females …