[HTML][HTML] CAR-T regulatory (CAR-Treg) cells: engineering and applications

M Arjomandnejad, AL Kopec, AM Keeler - Biomedicines, 2022 - mdpi.com
Regulatory T cells are critical for maintaining immune tolerance. Recent studies have
confirmed their therapeutic suppressive potential to modulate immune responses in organ …

[HTML][HTML] Regulatory CAR-T cells in autoimmune diseases: Progress and current challenges

T Riet, M Chmielewski - Frontiers in Immunology, 2022 - frontiersin.org
CAR (Chimeric Antigen Receptor) T-cell therapy has revolutionized the field of oncology in
recent years. This innovative shift in cancer treatment also provides the opportunity to …

Building a CAR-Treg: going from the basic to the luxury model

I Rosado-Sanchez, MK Levings - Cellular Immunology, 2020 - Elsevier
Regulatory T cells (Tregs) control immune homeostasis and prevent exacerbated immune
responses, and can be used as cell therapy to dampen a variety of autoimmune or …

[HTML][HTML] The future of regulatory T cell therapy: promises and challenges of implementing CAR technology

YR Mohseni, SL Tung, C Dudreuilh, RI Lechler… - Frontiers in …, 2020 - frontiersin.org
Cell therapy with polyclonal regulatory T cells (Tregs) has been translated into the clinic and
is currently being tested in transplant recipients and patients suffering from autoimmune …

[HTML][HTML] Chimeric antigen receptor (CAR) Treg: a promising approach to inducing immunological tolerance

Q Zhang, W Lu, CL Liang, Y Chen, H Liu… - Frontiers in …, 2018 - frontiersin.org
Cellular therapies with polyclonal regulatory T-cells (Tregs) in transplantation and
autoimmune diseases have been carried out in both animal models and clinical trials …

[HTML][HTML] The next frontier of regulatory T cells: Promising immunotherapy for autoimmune diseases and organ transplantations

LV Terry, YH Oo - Frontiers in immunology, 2020 - frontiersin.org
Regulatory T cells (Tregs) are crucial in maintaining tolerance. Hence, Treg immunotherapy
is an attractive therapeutic option in autoimmune diseases and organ transplantations …

[HTML][HTML] Chimeric antigen receptor (CAR) regulatory T-cells in solid organ transplantation

I Gille, FHJ Claas, GW Haasnoot… - Frontiers in …, 2022 - frontiersin.org
Solid organ transplantation is the treatment of choice for various end-stage diseases, but
requires the continuous need for immunosuppression to prevent allograft rejection. This …

[HTML][HTML] Antigen specific regulatory T cells in kidney transplantation and other tolerance settings

M Hu, NM Rogers, J Li, GY Zhang, YM Wang… - Frontiers in …, 2021 - frontiersin.org
Kidney transplantation is the most common solid organ transplant and the best current
therapy for end-stage kidney failure. However, with standard immunosuppression, most …

[HTML][HTML] Regulatory T cells as immunotherapy

BD Singer, LS King, FR D'Alessio - Frontiers in immunology, 2014 - frontiersin.org
Regulatory T cells (Tregs) suppress exuberant immune system activation and promote
immunologic tolerance. Because Tregs modulate both innate and adaptive immunity, the …

Regulatory T cell therapy: current and future design perspectives

J Rana, M Biswas - Cellular immunology, 2020 - Elsevier
Regulatory T cells (Tregs) maintain immune equilibrium by suppressing immune responses
through various multistep contact dependent and independent mechanisms. Cellular …