The protein kinase ataxia telangiectasia mutated (ATM) is a master regulator of double-
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …

Ataxia‐telangiectasia (A‐T) is characterized by neuronal degeneration, cancer, diabetes,
immune deficiency, and increased sensitivity to ionizing radiation. A‐T is attributed to the …

Ataxia telangiectasia (AT) results from inactivation of the ATM protein kinase. DNA-damage
signaling is a prime function of this kinase, although other roles have been ascribed to ATM …

Ataxia telangiectasia (AT) has long intrigued the biomedical research community owing to
the spectrum of defects that are characteristic of the disease, including neurodegeneration …

ATM kinase, the product of the ataxia telangiectasia mutated (Atm) gene, is activated by
genomic damage. ATM plays a crucial role in cell growth and development. Here we report …

The protein kinase ataxia-telangiectasia mutated (ATM) is best known for its role as an
apical activator of the DNA damage response in the face of DNA double-strand breaks …

One of the cornerstones of the web of signaling pathways governing cellular life and
differentiation is the DNA damage response. It spans a complex network of pathways …

The ATM protein kinase is the product of the gene responsible for the pleiotropic recessive
disorder ataxia-telangiectasia. ATM-deficient cells show enhanced sensitivity and greatly …

The protein kinase ATM is a master regulator of the DNA damage response but also
responds directly to oxidative stress. Loss of ATM causes ataxia telangiectasia, a …

Ataxia telangiectasia (AT) mutated (ATM) is a key deoxyribonucleic acid (DNA) damage
signaling kinase that regulates DNA repair, cell cycle checkpoints, and apoptosis. The …