Non-nucleoside reverse transcriptase inhibitors (NNRTIs), their discovery, development, and use in the treatment of HIV-1 infection: a review of the last 20 years (1989 …
MP de Béthune - Antiviral research, 2010 - Elsevier
It is almost 20 years since NNRTIs were identified as a new class of antiretroviral drugs for
the treatment of HIV-1 infection. Although they belong to different and diverse chemical …
the treatment of HIV-1 infection. Although they belong to different and diverse chemical …
Non-nucleoside reverse transcriptase inhibitors: the NNRTI boom
OS Pedersen, EB Pedersen - Antiviral Chemistry and …, 1999 - journals.sagepub.com
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are promising drugs for the
treatment of HIV when used in combination with other anti-HIV drugs such as nucleoside …
treatment of HIV when used in combination with other anti-HIV drugs such as nucleoside …
The journey of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) from lab to clinic
V Namasivayam, M Vanangamudi… - Journal of medicinal …, 2018 - ACS Publications
Human immunodeficiency virus (HIV) infection is now pandemic. Targeting HIV-1 reverse
transcriptase (HIV-1 RT) has been considered as one of the most successful targets for the …
transcriptase (HIV-1 RT) has been considered as one of the most successful targets for the …
Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors: past, present, and future perspectives
G Campiani, A Ramunno, G Maga… - Current …, 2002 - ingentaconnect.com
Along with nucleoside reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs),
nonnucleoside reverse transcriptase inhibitors (NNRTIs) have gained a definitive and …
nonnucleoside reverse transcriptase inhibitors (NNRTIs) have gained a definitive and …
The role of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection
E De Clercq - Antiviral research, 1998 - Elsevier
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) have, in addition to the nucleoside
reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs), gained a definitive …
reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs), gained a definitive …
Current status of the non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1
J Balzarini - Current topics in medicinal chemistry, 2004 - ingentaconnect.com
Almost fifteen years ago, the first non-nucleoside reverse transcriptase (RT) inhibitor
(NNRTI) lead compounds have been discovered. Nowadays, three NNRTIs are approved for …
(NNRTI) lead compounds have been discovered. Nowadays, three NNRTIs are approved for …
Non‐nucleoside reverse transcriptase inhibitors (NNRTIs): past, present, and future
E De Clercq - Chemistry & biodiversity, 2004 - Wiley Online Library
Non‐nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) have become an inherent
ingredient of the drug combination schemes that are currently used in the treatment of …
ingredient of the drug combination schemes that are currently used in the treatment of …
Perspectives of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection
E De Clercq - Il Farmaco, 1999 - Elsevier
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) have, in addition to the nucleoside
reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs), gained a definitive …
reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs), gained a definitive …
Current and emerging non-nucleoside reverse transcriptase inhibitors (NNRTIs) for HIV-1 treatment
Y Wang, E De Clercq, G Li - Expert opinion on drug metabolism & …, 2019 - Taylor & Francis
Introduction: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are essential
components of highly active antiretroviral therapy against HIV-1 infections. Here, we provide …
components of highly active antiretroviral therapy against HIV-1 infections. Here, we provide …
Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine
T Cihlar, AS Ray - Antiviral research, 2010 - Elsevier
Twenty-five years ago, nucleoside analog 3′-azidothymidine (AZT) was shown to efficiently
block the replication of HIV in cell culture. Subsequent studies demonstrated that AZT acts …
block the replication of HIV in cell culture. Subsequent studies demonstrated that AZT acts …