A review of disintegration mechanisms and measurement techniques
D Markl, JA Zeitler - Pharmaceutical research, 2017 - Springer
Pharmaceutical solid dosage forms (tablets or capsules) are the predominant form to
administer active pharmaceutical ingredients (APIs) to the patient. Tablets are typically …
administer active pharmaceutical ingredients (APIs) to the patient. Tablets are typically …
Modeling and comparison of dissolution profiles
P Costa, JMS Lobo - European journal of pharmaceutical sciences, 2001 - Elsevier
Over recent years, drug release/dissolution from solid pharmaceutical dosage forms has
been the subject of intense and profitable scientific developments. Whenever a new solid …
been the subject of intense and profitable scientific developments. Whenever a new solid …
Dynamic dissolution: a step closer to predictive dissolution testing?
M McAllister - Molecular pharmaceutics, 2010 - ACS Publications
The use of compendial dissolution techniques to characterize the performance of oral drug
delivery systems is an established area of pharmaceutical science. However, compendial …
delivery systems is an established area of pharmaceutical science. However, compendial …
Mathematical modeling of drug dissolution
J Siepmann, F Siepmann - International journal of pharmaceutics, 2013 - Elsevier
The dissolution of a drug administered in the solid state is a pre-requisite for efficient
subsequent transport within the human body. This is because only dissolved drug …
subsequent transport within the human body. This is because only dissolved drug …
Kinetic modeling to explain the release of medicine from drug delivery systems
M Askarizadeh, N Esfandiari, B Honarvar… - ChemBioEng …, 2023 - Wiley Online Library
Proper medication dissolution must be ensured when developing or manufacturing a new
solid dosage form. Quantitative analyses performed in dissolution or release tests become …
solid dosage form. Quantitative analyses performed in dissolution or release tests become …
Exploring the performance-controlling tablet disintegration mechanisms for direct compression formulations
N Maclean, E Walsh, M Soundaranathan… - International Journal of …, 2021 - Elsevier
The design and manufacture of tablets is a challenging process due to the complex
interrelationships between raw material properties, the manufacturing settings and the tablet …
interrelationships between raw material properties, the manufacturing settings and the tablet …
Determination of the in vitro disintegration profile of rapidly disintegrating tablets and correlation with oral disintegration
G Abdelbary, C Eouani, P Prinderre, J Joachim… - International journal of …, 2005 - Elsevier
The assessment of the in vitro disintegration profile of rapidly disintegrating tablets (RDT) is
very important in the evaluation and the development of new formulations of this type. So far …
very important in the evaluation and the development of new formulations of this type. So far …
Advancing the understanding of the tablet disintegration phenomenon–an update on recent studies
Disintegration is the de-aggregation of particles within tablets upon exposure to aqueous
fluids. Being an essential step in the bioavailability cascade, disintegration is a fundamental …
fluids. Being an essential step in the bioavailability cascade, disintegration is a fundamental …
Evaluation of the DDSolver software applications
J Zuo, Y Gao, N Bou-Chacra… - BioMed research …, 2014 - Wiley Online Library
When a new oral dosage form is developed, its dissolution behavior must be quantitatively
analyzed. Dissolution analysis involves a comparison of the dissolution profiles and the …
analyzed. Dissolution analysis involves a comparison of the dissolution profiles and the …
Review of disintegrants and the disintegration phenomena
Disintegrant is one of the most important components in a typical tablet dosage form. It is
responsible for ensuring the break-up of the tablet matrix upon ingestion. Disintegrants act …
responsible for ensuring the break-up of the tablet matrix upon ingestion. Disintegrants act …