Pharmaceutical solid dosage forms (tablets or capsules) are the predominant form to
administer active pharmaceutical ingredients (APIs) to the patient. Tablets are typically …

Over recent years, drug release/dissolution from solid pharmaceutical dosage forms has
been the subject of intense and profitable scientific developments. Whenever a new solid …

The use of compendial dissolution techniques to characterize the performance of oral drug
delivery systems is an established area of pharmaceutical science. However, compendial …

The dissolution of a drug administered in the solid state is a pre-requisite for efficient
subsequent transport within the human body. This is because only dissolved drug …

Proper medication dissolution must be ensured when developing or manufacturing a new
solid dosage form. Quantitative analyses performed in dissolution or release tests become …

The design and manufacture of tablets is a challenging process due to the complex
interrelationships between raw material properties, the manufacturing settings and the tablet …

The assessment of the in vitro disintegration profile of rapidly disintegrating tablets (RDT) is
very important in the evaluation and the development of new formulations of this type. So far …

Disintegration is the de-aggregation of particles within tablets upon exposure to aqueous
fluids. Being an essential step in the bioavailability cascade, disintegration is a fundamental …

When a new oral dosage form is developed, its dissolution behavior must be quantitatively
analyzed. Dissolution analysis involves a comparison of the dissolution profiles and the …

Disintegrant is one of the most important components in a typical tablet dosage form. It is
responsible for ensuring the break-up of the tablet matrix upon ingestion. Disintegrants act …