Bicyclic nucleosides and conformational restriction of oligonucleotides - Journal of the Chemical
Society, Perkin Transactions 1 (RSC Publishing) DOI:10.1039/B000114G Royal Society of …

The 3′-C-allyl furanose 4 has been used as a precursor for synthesis of the novel 2′-O,
3′-C-linked bicyclic thymine nucleosides 15, 16, 20 and 25. The three bicyclic β …

2'Pr2N 3 4 “(a) Pivaloyl chloride (1.2 equiv), pyridine,-15 C, 3 h, 75%.(b) Paraformaldehyde
(2.0 equiv); HCl (g), dichloromethane. 13 (c) Bis-(trimethylsilyl) thymine (1.2 equiv). Bu4NI …

A tricyclic nucleoside is synthesised from a bicyclic nucleoside precursor by applying a
stereoselective dihydroxylation, a regioselective tosylation and an intramolecular ether …

The immense potential of oligonucleotide analogues as therapeutic agents or diagnostic
molecules has stimulated intensive research on nucleic acid mimics during the last years. 1 …

1-α-O-Methyl-3-O, 5-O-TIPDS-arabinose was converted, in multiple steps, to 2, 6-dioxa-
bicyclo [3, 2, 1] octane derivatives, which were condensed with silylated nucleoside bases to …

A conformationally locked, 2′, 4′-C-bridged 2′-deoxyribofuranoside2 was condensed
with silylated pyrimidines to give 2′, 4′-C-bridged bicyclonucleosides, which were …

To find an oligodeoxynucleotide (ODN) with triplex stabilization capability, we designed and
synthesized novel branched ODNs 1 and 2 with pentaerythritols at their branch points …

The proposal to use synthetic antisense oligonucleotides for therapeutic purposes* 1 has
led to a great interest in the modification of natural DNA and RNA molecules by chemical …

The need to protect the amino groups of nucleoside bases was recognized early in the
development of chemical methods for synthesizing oligonucleotides. 1, 2 Since then, N …