Bile acid signaling in neurodegenerative and neurological disorders

SM Grant, S DeMorrow - International Journal of Molecular Sciences, 2020 - mdpi.com
Bile acids are commonly known as digestive agents for lipids. The mechanisms of bile acids
in the gastrointestinal track during normal physiological conditions as well as hepatic and …

[HTML][HTML] Bile acids and neurological disease

MJ Hurley, R Bates, J Macnaughtan… - Pharmacology & …, 2022 - Elsevier
This review will focus on how bile acids are being used in clinical trials to treat neurological
diseases due to their central involvement with the gut-liver-brain axis and their physiological …

Roles of bile acids signaling in neuromodulation under physiological and pathological conditions

C Xing, X Huang, D Wang, D Yu, S Hou, H Cui, L Song - Cell & bioscience, 2023 - Springer
Bile acids (BA) are important physiological molecules not only mediating nutrients
absorption and metabolism in peripheral tissues, but exerting neuromodulation effect in the …

[HTML][HTML] Effects of bile acids on neurological function and disease

M McMillin, S DeMorrow - The FASEB Journal, 2016 - ncbi.nlm.nih.gov
Bile acids are synthesized from cholesterol and are known to be involved with the
emulsification and digestion of dietary lipids and fat-soluble vitamins. Outside of this role …

Bile acids in neurodegenerative disorders

HD Ackerman, GS Gerhard - Frontiers in aging neuroscience, 2016 - frontiersin.org
Bile acids, a structurally related group of molecules derived from cholesterol, have a long
history as therapeutic agents in medicine, from treatment for primarily ocular diseases in …

Bile acid signaling pathways from the enterohepatic circulation to the central nervous system

KL Mertens, A Kalsbeek, MR Soeters… - Frontiers in …, 2017 - frontiersin.org
Bile acids are best known as detergents involved in the digestion of lipids. In addition, new
data in the last decade have shown that bile acids also function as gut hormones capable of …

Bile acids: a communication channel in the gut-brain axis

VF Monteiro-Cardoso, M Corlianò… - NeuroMolecular …, 2021 - Springer
Bile acids are signalling hormones involved in the regulation of several metabolic pathways.
The ability of bile acids to bind and signal through their receptors is modulated by the gut …

Bile acid signaling in metabolic disease and drug therapy

T Li, JYL Chiang - Pharmacological reviews, 2014 - ASPET
Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis
accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile …

[HTML][HTML] Bile acid metabolism and signaling

JYL Chiang - Comprehensive physiology, 2013 - ncbi.nlm.nih.gov
Bile acids are important physiological agents for intestinal nutrient absorption and biliary
secretion of lipids, toxic metabolites, and xenobiotics. Bile acids also are signaling …

Bile acids as regulatory molecules and potential targets in metabolic diseases

A Xie, C Mai, YZ Zhu, XC Liu, Y Xie - Life Sciences, 2021 - Elsevier
Bile acids are important hydroxylated steroids that are synthesized in the liver from
cholesterol for intestinal absorption of lipids and other fatty-nutrient. They also display …