The Role of Shear Stress in Coronary Artery Disease

G Siasos, V Tsigkou, AU Coskun… - Current Topics in …, 2023 - ingentaconnect.com
Coronary artery disease is the leading cause of morbidity and mortality worldwide,
especially in developed countries, with an increasing incidence in developing countries …

Shear stress, protein kinases and atherosclerosis

G Siasos, D Tousoulis, Z Siasou… - Current medicinal …, 2007 - ingentaconnect.com
Shear stress represents the frictional force that the flow of blood exerts at the endothelial
surface of the vessel wall and plays a central role in cell function and structure via managing …

Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior

YS Chatzizisis, AU Coskun, M Jonas… - Journal of the American …, 2007 - jacc.org
Although the entire coronary tree is exposed to the atherogenic effect of the systemic risk
factors, atherosclerotic lesions form at specific arterial regions, where low and oscillatory …

Role of biomechanical forces in the natural history of coronary atherosclerosis

AJ Brown, Z Teng, PC Evans, JH Gillard… - Nature reviews …, 2016 - nature.com
Atherosclerosis remains a major cause of morbidity and mortality worldwide, and a thorough
understanding of the underlying pathophysiological mechanisms is crucial for the …

Endothelial shear stress signal transduction and atherogenesis: from mechanisms to therapeutics

L He, CL Zhang, Q Chen, L Wang, Y Huang - Pharmacology & therapeutics, 2022 - Elsevier
Atherosclerotic vascular disease and its complications are among the top causes of mortality
worldwide. In the vascular lumen, atherosclerotic plaques are not randomly distributed …

Hemodynamic shear stress and its role in atherosclerosis

AM Malek, SL Alper, S Izumo - Jama, 1999 - jamanetwork.com
Atherosclerosis, the leading cause of death in the developed world and nearly the leading
cause in the developing world, is associated with systemic risk factors including …

Wall shear stress and its role in atherosclerosis

M Zhou, Y Yu, R Chen, X Liu, Y Hu, Z Ma… - Frontiers in …, 2023 - frontiersin.org
Atherosclerosis (AS) is the major form of cardiovascular disease and the leading cause of
morbidity and mortality in countries around the world. Atherosclerosis combines the …

Shear stress and plaque development

SS Dhawan, RP Avati Nanjundappa… - Expert review of …, 2010 - Taylor & Francis
Although traditional cardiovascular risk factors 'prime the soil'for atherogenesis systemically,
atherosclerosis primarily occurs in a site-specific manner with a predilection towards the …

How do we prevent the vulnerable atherosclerotic plaque from rupturing? Insights from in vivo assessments of plaque, vascular remodeling, and local endothelial …

I Andreou, AP Antoniadis, K Shishido… - Journal of …, 2015 - journals.sagepub.com
Coronary atherosclerosis progresses both as slow, gradual enlargement of focal plaque and
also as a more dynamic process with periodic abrupt changes in plaque geometry, size, and …

[HTML][HTML] The role of shear stress in the pathogenesis of atherosclerosis

KS Cunningham, AI Gotlieb - Laboratory investigation, 2005 - Elsevier
Although the pathobiology of atherosclerosis is a complex multifactorial process, blood flow-
induced shear stress has emerged as an essential feature of atherogenesis. This fluid drag …