Peptides are known to play many important physiological roles in signaling. A large number
of peptides have been detected in mouse brain extracts using mass spectrometry-based …

This review focuses on the contributions of modern mass spectrometry to neuropeptide
research. An introduction to newer mass spectrometric techniques is provided. Also, the use …

The function and activity of almost every circuit in the human brain are modified by the
signaling peptides (SPs) surrounding the neurons. As the complement of peptides can vary …

THAT MAY LEAD TO BIOMARKERS. he characterization of genomes of an ever-growing
number of species, including the human genome, has provided new technologies and …

Neuropeptides perform a large variety of functions as intercellular signaling molecules.
While most proteomic studies involve digestion of the proteins with trypsin or other …

Mass spectrometry-based neuropeptidomics is one of the most powerful approaches for
identification of endogenous neuropeptides in the brain. Until now, however, the …

Neuropeptides are important mediators in the functionality of the brain and other
neurological organs. Because neuropeptides exist in a wide range of concentrations …

Neuropeptidomics refers to a global characterization approach for the investigation of
neuropeptides, often under specific physiological conditions. Neuropeptides comprise a …

Due to their involvement in numerous biochemical pathways, neuropeptides have been the
focus of many recent research studies. Unfortunately, classic analytical methods, such as …

Modern proteomic methodologies have significantly improved the possibilities of large-scale
identification of proteins. However, these methodologies are limited by their inability to …