Gentiopicroside and swertiamarin induce non-selective oxidative stress-mediated cytotoxic effects in human peripheral blood mononuclear cells

AV Šobot, D Drakulić, A Todorović, M Janić… - Chemico-Biological …, 2024 - Elsevier
Abstract Gentiopicroside (Gp) and swertiamarin (Sm), secoiridoid glycosides commonly
found in plants of the Gentianaceae family, differ in one functional group. They exhibit …

Attenuation of oxidative stress in HEK 293 cells by the TCM constituents schisanhenol, baicalein, resveratrol or crocetin and two defined mixtures

JR Bend, XY Xia, D Chen, A Awaysheh, A Lo… - Journal of Pharmacy …, 2015 - ir.lib.uwo.ca
PURPOSE: Our working hypothesis is that single bioactive phytochemicals with antioxidant
properties that are important constituents of Traditional Chinese Medicine (TCM) and their …

Comparative antioxidant, prooxidant and cytotoxic activity of sigmoidin A and eriodictyol

S Habtemariam, E Dagne - Planta Medica, 2010 - thieme-connect.com
Sigmoidin A (SGN) is a prenylated flavanone derivative of eriodictyol (ERD) with reported
moderate antioxidant, antimicrobial and anti-inflammatory activity. Since ERD and other …

Rapid and transient intracellular oxidative stress due to novel macrosphelides trigger apoptosis via Fas/caspase-8-dependent pathway in human lymphoma U937 …

K Ahmed, QL Zhao, Y Matsuya, DY Yu… - Chemico-biological …, 2007 - Elsevier
The ability of the derivatives of macrosphelides (MS) core (simplified 16-membered core
structure of natural MS) to induce apoptosis in human lymphoma U937 cells was …

Antioxidant, Cytotoxic, and Antiproliferative Activities and Total Polyphenol Contents of the Extracts of Geissospermum reticulatum Bark

JJ Sajkowska-Kozielewicz… - Oxidative medicine …, 2016 - Wiley Online Library
Geissospermum species are medically important plants due to their health‐promoting
effects. The objective of this study was to determine the antioxidant ability and …

Genista sessilifolia DC. and Genista tinctoria L. inhibit UV light and nitric oxide-induced DNA damage and human melanoma cell growth

D Rigano, V Cardile, C Formisano, MT Maldini… - Chemico-biological …, 2009 - Elsevier
Many Genista species (Leguminosae), containing isoflavones as biologically active
substances, show interesting biological properties such as hypoglycemic, antiinflammatory …

Activity of three cytotoxic isoflavonoids from Erythrina excelsa and Erythrina senegalensis (neobavaisoflavone, sigmoidin H and isoneorautenol) toward multi-factorial …

V Kuete, LP Sandjo, GMN Kwamou, B Wiench… - Phytomedicine, 2014 - Elsevier
Introduction Resistance of cancer cells to chemotherapy has become a worldwide concern.
Naturally occuring isoflavonoids possess a variety of biological activities including anti …

Cytotoxic flavonoids and isoflavonoids from Erythrina sigmoidea towards multi-factorial drug resistant cancer cells

V Kuete, LP Sandjo, DE Djeussi, M Zeino… - Investigational New …, 2014 - Springer
Introduction Continuous efforts from scientists of diverse fields are necessary not only to
better understand the mechanism by which multidrug resistant (MDR) cancer cells occur, but …

Ethyl acetate crude fraction of Macaranga subpeltata and silymarin increase Vero cell survival and HepG2 cell death due to oxidative stress

H Widodo, A Rohman - Journal of Applied Pharmaceutical Science, 2023 - japsonline.com
Reactive oxygen species (ROS) trigger oxidative stress (OS) that determines the onset of
aging and various disease progressions including cancer. Macaranga subpeltata is among …

[HTML][HTML] Boesenbergia stenophylla-Derived Stenophyllol B Exerts Antiproliferative and Oxidative Stress Responses in Triple-Negative Breast Cancer Cells with Few …

MY Lee, JP Shiau, JY Tang, MF Hou… - International Journal of …, 2023 - mdpi.com
Triple-negative breast cancer (TNBC) is insensitive to target therapy for non-TNBC and
needs novel drug discovery. Extracts of the traditional herb Boesenbergia plant in Southern …