Natural killer cell dysfunction in hepatocellular carcinoma and NK cell-based immunotherapy

C Sun, H Sun, W Xiao, C Zhang, Z Tian - Acta Pharmacologica Sinica, 2015 - nature.com
The mechanisms linking hepatitis B virus (HBV) and hepatitis C virus (HCV) infection to
hepatocellular carcinoma (HCC) remain largely unknown. Natural killer (NK) cells account …

Natural killer cells in liver disease and hepatocellular carcinoma and the NK cell‐based immunotherapy

P Liu, L Chen, H Zhang - Journal of Immunology Research, 2018 - Wiley Online Library
Nature killer (NK) cells play a critical role in host innate and adaptive immune defense
against viral infections and tumors. NK cells are enriched in liver hematopoietic cells with …

NK cell receptor imbalance and NK cell dysfunction in HBV infection and hepatocellular carcinoma

C Sun, H Sun, C Zhang, Z Tian - Cellular & molecular immunology, 2015 - nature.com
Hepatocellular carcinoma (HCC) is currently the third leading cause of cancer mortality and
a common poor-prognosis malignancy due to postoperative recurrence and metastasis …

[HTML][HTML] The dynamic role of NK cells in liver cancers: role in HCC and HBV associated HCC and its therapeutic implications

M Sajid, L Liu, C Sun - Frontiers in Immunology, 2022 - frontiersin.org
Hepatocellular carcinoma (HCC) remains an important complication of chronic liver disease,
especially when cirrhosis occurs. Existing treatment strategies include surgery, loco-regional …

Natural killer cell dysfunction in hepatocellular carcinoma: pathogenesis and clinical implications

PS Sung, JW Jang - International journal of molecular sciences, 2018 - mdpi.com
Hepatocellular carcinoma (HCC) is currently the third leading cause of malignancy-related
mortalities worldwide. Natural killer (NK) cells are involved in the critical role of first line …

Activity of IL-12/15/18 primed natural killer cells against hepatocellular carcinoma

L Zhuang, RJ Fulton, P Rettman, AE Sayan… - Hepatology …, 2019 - Springer
Background Hepatocellular carcinoma (HCC) is common, but remains difficult to treat.
Natural killer (NK) cells are cells of the innate immune system that have potent anti-cancer …

Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients

L Cai, Z Zhang, L Zhou, H Wang, J Fu, S Zhang… - Clinical …, 2008 - Elsevier
Functional defects in natural killer (NK) cells have been proposed to be responsible for the
failure of anti-tumor immune responses. Whether and how NK cells are impaired in …

Expanded and activated natural killer cells for immunotherapy of hepatocellular carcinoma

T Kamiya, YH Chang, D Campana - Cancer immunology research, 2016 - AACR
Viral infection of the liver is a major risk factor for hepatocellular carcinoma (HCC). Natural
killer (NK) cells recognize virally infected and oncogenically transformed cells, suggesting a …

Natural killer cell functional dichotomy in chronic hepatitis B and chronic hepatitis C virus infections

B Oliviero, S Varchetta, E Paudice, G Michelone… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: The phenotypic and functional characteristics of natural killer (NK)
cells in chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are …

Natural killer cells and T cells in hepatocellular carcinoma and viral hepatitis: current status and perspectives for future immunotherapeutic approaches

SG Kalathil, Y Thanavala - Cells, 2021 - mdpi.com
Natural killer (NK) cells account for 25–50% of the total number of hepatic lymphocytes,
which implicates that NK cells play an important role in liver immunity. The frequencies of …