Melanoma is the most lethal type of skin cancer, originating from the malignant
transformation of melanocyte. While the development of targeted therapy and …

Melanoma is an aggressive skin cancer that can rapidly metastasize to become fatal, if not
diagnosed early. Despite recent therapeutic advances, management of melanoma remains …

ABSTRACT SIRT1 is a highly conserved NAD+-dependent protein deacetylase that is
involved in diverse cellular processes. SIRT1 can deacetylate not only histones, but also a …

Melanoma is among the most life-threatening cancers. The pathogenesis of melanoma has
not been fully elucidated. Recently, dysregulated macroautophagy/autophagy has been …

Melanoma is highly metastatic, and understanding of its molecular mechanism is urgently
needed for the development of therapeutic targets and prognostic assessment for metastatic …

Melanoma is one of the most lethal forms of skin cancer and its incidence is continuing to
rise in the United States. Therefore, novel mechanism and target-based strategies are …

Sirtuins are NAD+-dependent deacetylases that regulate numerous cellular processes
including aging, DNA repair, cell cycle, metabolism, and survival under stress conditions …

Melanoma, the most aggressive form of skin cancer, is often fatal if not treated early.
Therefore, novel target-based strategies are required to combat this neoplasm. The …

Melanoma is the most notorious and fatal of all skin cancers and the existing treatment
options have not been proven to effectively manage this neoplasm, especially the metastatic …

Abstract Background Sirtuin 6 (SIRT6) is a NAD+-dependent deacetylase with key roles in
cell metabolism. High SIRT6 expression is associated with adverse prognosis in breast …