The ins and outs of the striatum: role in drug addiction
Addiction is a chronic relapsing disorder characterized by the loss of control over drug
intake, high motivation to obtain the drug, and a persistent craving for the drug …
intake, high motivation to obtain the drug, and a persistent craving for the drug …
[HTML][HTML] From the ventral to the dorsal striatum: devolving views of their roles in drug addiction
BJ Everitt, TW Robbins - Neuroscience & Biobehavioral Reviews, 2013 - Elsevier
We revisit our hypothesis that drug addiction can be viewed as the endpoint of a series of
transitions from initial voluntarily drug use to habitual, and ultimately compulsive drug use …
transitions from initial voluntarily drug use to habitual, and ultimately compulsive drug use …
It could be habit forming: drugs of abuse and striatal synaptic plasticity
Drug addiction can take control of the brain and behavior, activating behavioral patterns that
are directed excessively and compulsively toward drug usage. Such patterns often involve …
are directed excessively and compulsively toward drug usage. Such patterns often involve …
Kicking the habit: the neural basis of ingrained behaviors in cocaine addiction
RC Pierce, LJMJ Vanderschuren - Neuroscience & Biobehavioral Reviews, 2010 - Elsevier
Cocaine addiction is a complex and multifaceted process encompassing a number of forms
of behavioral plasticity. The process of acquiring and consuming drugs can be sufficiently …
of behavioral plasticity. The process of acquiring and consuming drugs can be sufficiently …
[HTML][HTML] The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neurons
MK Lobo, EJ Nestler - Frontiers in neuroanatomy, 2011 - frontiersin.org
The striatum plays a key role in mediating the acute and chronic effects of addictive drugs,
with drugs of abuse causing long-lasting molecular and cellular alterations in both dorsal …
with drugs of abuse causing long-lasting molecular and cellular alterations in both dorsal …
Integrating synaptic plasticity and striatal circuit function in addiction
Exposure to addictive drugs causes changes in synaptic function within the striatal complex,
which can either mimic or interfere with the induction of synaptic plasticity. These synaptic …
which can either mimic or interfere with the induction of synaptic plasticity. These synaptic …
[HTML][HTML] Glutamatergic synaptic plasticity in the mesocorticolimbic system in addiction
AN van Huijstee, HD Mansvelder - Frontiers in cellular neuroscience, 2015 - frontiersin.org
Addictive drugs remodel the brain's reward circuitry, the mesocorticolimbic dopamine (DA)
system, by inducing widespread adaptations of glutamatergic synapses. This drug-induced …
system, by inducing widespread adaptations of glutamatergic synapses. This drug-induced …
Dopamine D2 receptors and striatopallidal transmission in addiction and obesity
PJ Kenny, G Voren, PM Johnson - Current opinion in neurobiology, 2013 - Elsevier
Highlights•Obesity and addiction result in diminished D2 receptor availability in striatum.•D2
receptors control compulsive eating.•DREADDs and optogenetics have revealed a key role …
receptors control compulsive eating.•DREADDs and optogenetics have revealed a key role …
The neural basis of addiction: a pathology of motivation and choice
PW Kalivas, ND Volkow - American Journal of Psychiatry, 2005 - Am Psychiatric Assoc
OBJECTIVE: A primary behavioral pathology in drug addiction is the overpowering
motivational strength and decreased ability to control the desire to obtain drugs. In this …
motivational strength and decreased ability to control the desire to obtain drugs. In this …
Parallel and interactive learning processes within the basal ganglia: relevance for the understanding of addiction
In this review we discuss the evidence that drug addiction, defined as a maladaptive
compulsive habit, results from the progressive subversion by addictive drugs of striatum …
compulsive habit, results from the progressive subversion by addictive drugs of striatum …