AmpC β-lactamases are clinically important cephalosporinases encoded on the
chromosomes of many of the Enterobacteriaceae and a few other organisms, where they …

AmpC β-lactamases have been a target of study since the late 1970s. Most of these
enzymes are cephalosporinases but are capable of hydrolysing all β-lactams to some …

Understanding the nuances of AmpC β-lactamase–mediated resistance can be challenging,
even for the infectious diseases specialist. AmpC resistance can be classified into 3 …

Although plasmid-mediated AmpC β-lactamases were first reported in the late 1980s, many
infectious disease personnel remain unaware of their clinical importance. These enzymes …

Two mechanisms account for AmpC activity in Escherichia coli, namely, mutations in the
ampC promoter and attenuator regions resulting in ampC overexpression and acquisition of …

The predominant mechanism for resistance to-lactam antibiotics in gram-negative bacteria is
the synthesis of-lactamase. To meet this challenge,-lactams with greater-lactamase stability …

Resistance to third-generation cephalosporins mediated by β-lactamases is an increasing
problem for clinical therapeutics. A wide range of Enterobacteriaceae produce these AmpC …

Objectives: To determine the distribution of acquired AmpC β-lactamases in 173 isolates of
Escherichia coli and Klebsiella spp. submitted to the UK's national reference laboratory for …

Some bacteria that possess chromosomally determined AmpC β-lactamases may express
these enzymes at a high level following exposure to β-lactams, either by induction or …

The aim of this study was to investigate the prevalences of plasmid-mediated AmpC β-
lactamases (PABLs) in isolates of Escherichia coli and Klebsiella spp. from a university …