[HTML][HTML] Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane
Early cancers are avascular and hence, profoundly acidic. Pre-malignant cells must adapt to
acidosis to thrive in this hostile microenvironment. Here, we investigate MCF-7 cells that are …
acidosis to thrive in this hostile microenvironment. Here, we investigate MCF-7 cells that are …
LAMP2A overexpression in breast tumors promotes cancer cell survival via chaperone-mediated autophagy
T Saha - Autophagy, 2012 - Taylor & Francis
Lysosome-associated membrane protein type 2A (LAMP2A) is a key protein in the
chaperone-mediated autophagy (CMA) pathway. LAMP2A helps in lysosomal uptake of …
chaperone-mediated autophagy (CMA) pathway. LAMP2A helps in lysosomal uptake of …
Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments
JW Wojtkowiak, JM Rothberg, V Kumar, KJ Schramm… - Cancer research, 2012 - AACR
Tumor cell survival relies upon adaptation to the acidic conditions of the tumor
microenvironment. To investigate potential acidosis survival mechanisms, we examined the …
microenvironment. To investigate potential acidosis survival mechanisms, we examined the …
[HTML][HTML] Tumor cells induce LAMP2a expression in tumor-associated macrophage for cancer progression
R Wang, Y Liu, L Liu, M Chen, X Wang, J Yang… - …, 2019 - thelancet.com
Background Tumor cells benefit from tumor-associated macrophages (TAMs) promoting
tumor growth and modulating functions of other cells in tumor microenvironment (TME) …
tumor growth and modulating functions of other cells in tumor microenvironment (TME) …
LAMPs: Shedding light on cancer biology
F Alessandrini, L Pezzè, Y Ciribilli - Seminars in oncology, 2017 - Elsevier
Lysosomes are important cytoplasmic organelles whose critical functions in cells are
increasingly being understood. In particular, despite the long-standing accepted concept …
increasingly being understood. In particular, despite the long-standing accepted concept …
Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy
EL Eskelinen - Molecular aspects of medicine, 2006 - Elsevier
The lysosomal membrane proteins LAMP-1 and LAMP-2 are estimated to contribute to about
50% of all proteins of the lysosome membrane. Surprisingly, mice deficient in either LAMP-1 …
50% of all proteins of the lysosome membrane. Surprisingly, mice deficient in either LAMP-1 …
[HTML][HTML] Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel
Maintaining a highly acidic lysosomal pH is central to cellular physiology. Here, we use
functional proteomics, single-particle cryo-EM, electrophysiology, and in vivo imaging to …
functional proteomics, single-particle cryo-EM, electrophysiology, and in vivo imaging to …
Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2
N Fehrenbacher, L Bastholm, T Kirkegaard-Sørensen… - Cancer research, 2008 - AACR
Expression and activity of lysosomal cysteine cathepsins correlate with the metastatic
capacity and aggressiveness of tumors. Here, we show that transformation of murine …
capacity and aggressiveness of tumors. Here, we show that transformation of murine …
Acidification of tumor at stromal boundaries drives transcriptome alterations associated with aggressive phenotypes
Acidosis is a fundamental feature of the tumor microenvironment, which directly regulates
tumor cell invasion by affecting immune cell function, clonal cell evolution, and drug …
tumor cell invasion by affecting immune cell function, clonal cell evolution, and drug …
Extracellular acidosis triggers a senescence‐like phenotype in human melanoma cells
I Böhme, A Bosserhoff - Pigment cell & melanoma research, 2020 - Wiley Online Library
Acidosis of the tumor microenvironment is a characteristic of solid tumors such as malignant
melanoma. Main causes of the extracellular acidification are metabolic alterations in cancer …
melanoma. Main causes of the extracellular acidification are metabolic alterations in cancer …