Early cancers are avascular and hence, profoundly acidic. Pre-malignant cells must adapt to
acidosis to thrive in this hostile microenvironment. Here, we investigate MCF-7 cells that are …

Lysosome-associated membrane protein type 2A (LAMP2A) is a key protein in the
chaperone-mediated autophagy (CMA) pathway. LAMP2A helps in lysosomal uptake of …

Tumor cell survival relies upon adaptation to the acidic conditions of the tumor
microenvironment. To investigate potential acidosis survival mechanisms, we examined the …

Background Tumor cells benefit from tumor-associated macrophages (TAMs) promoting
tumor growth and modulating functions of other cells in tumor microenvironment (TME) …

Lysosomes are important cytoplasmic organelles whose critical functions in cells are
increasingly being understood. In particular, despite the long-standing accepted concept …

The lysosomal membrane proteins LAMP-1 and LAMP-2 are estimated to contribute to about
50% of all proteins of the lysosome membrane. Surprisingly, mice deficient in either LAMP-1 …

Maintaining a highly acidic lysosomal pH is central to cellular physiology. Here, we use
functional proteomics, single-particle cryo-EM, electrophysiology, and in vivo imaging to …

Expression and activity of lysosomal cysteine cathepsins correlate with the metastatic
capacity and aggressiveness of tumors. Here, we show that transformation of murine …

Acidosis is a fundamental feature of the tumor microenvironment, which directly regulates
tumor cell invasion by affecting immune cell function, clonal cell evolution, and drug …

Acidosis of the tumor microenvironment is a characteristic of solid tumors such as malignant
melanoma. Main causes of the extracellular acidification are metabolic alterations in cancer …