Neurovascular and cognitive dysfunction in hypertension: epidemiology, pathobiology, and treatment

C Iadecola, RF Gottesman - Circulation research, 2019 - Am Heart Assoc
Hypertension has emerged as a leading cause of age-related cognitive impairment. Long
known to be associated with dementia caused by vascular factors, hypertension has more …

Hypertension, neurovascular dysfunction, and cognitive impairment

MM Santisteban, C Iadecola, D Carnevale - Hypertension, 2023 - Am Heart Assoc
Hypertension affects a significant proportion of the adult and aging population and
represents an important risk factor for vascular cognitive impairment and late-life dementia …

Hypertension, brain damage and cognitive decline

D Gąsecki, M Kwarciany, W Nyka… - Current hypertension …, 2013 - Springer
Loss of cognitive function is one the most devastating manifestations of ageing and vascular
disease. Cognitive decline is rapidly becoming an important cause of disability worldwide …

Hypertension-induced cognitive impairment: from pathophysiology to public health

Z Ungvari, P Toth, S Tarantini, CI Prodan… - Nature Reviews …, 2021 - nature.com
Hypertension affects two-thirds of people aged> 60 years and significantly increases the risk
of both vascular cognitive impairment and Alzheimer's disease. Hypertension compromises …

Hypertension and mild cognitive impairment

C Sierra, M Doménech, M Camafort, A Coca - Current hypertension …, 2012 - Springer
The brain is an early target for organ damage due to high blood pressure. Hypertension is
the major modifiable risk factor for stroke and small vessel disease. It has been suggested …

Defining the relationship between hypertension, cognitive decline, and dementia: a review

KA Walker, MC Power, RF Gottesman - Current hypertension reports, 2017 - Springer
Hypertension is a highly prevalent condition which has been established as a risk factor for
cardiovascular and cerebrovascular disease. Although the understanding of the relationship …

Hypertension and cognitive impairment: a review of mechanisms and key concepts

M Canavan, MJ O'Donnell - Frontiers in Neurology, 2022 - frontiersin.org
Cognitive impairment, and dementia, are major contributors to global burden of death and
disability, with projected increases in prevalence in all regions of the world, but most marked …

Hypertension and dementia: epidemiological and experimental evidence revealing a detrimental relationship

M Perrotta, G Lembo, D Carnevale - International journal of molecular …, 2016 - mdpi.com
Hypertension and dementia represent two major public health challenges worldwide,
notably in the elderly population. Although these two conditions have classically been …

Hypertension and its role in cognitive function: current evidence and challenges for the future

TM Hughes, KM Sink - American journal of hypertension, 2016 - academic.oup.com
This review summarizes evidence from studies of blood pressure and dementia-related
biomarkers into our understanding of cognitive health and highlights the challenges facing …

Hypertension and cerebrovascular dysfunction

C Iadecola, RL Davisson - Cell metabolism, 2008 - cell.com
Essential hypertension has devastating effects on the brain, being the major cause of stroke
and a leading cause of dementia. Hypertension alters the structure of cerebral blood vessels …