1 Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, capsaicin. The
present study shows the capsazepine acts as a competitive antagonist of capsaicin. 2 …

1 Capsazepine has recently been described as a competitive capsaicin antagonist. We have
used this compound to test the hypotheses that the in vitro and in vivo effects of capsaicin …

This study was designed to investigate the antinociceptive activity of capsaicin in acute and
persistent nocifensor behavioural models and to determine whether this was mediated via a …

Capsaicin and resiniferatoxin are natural products which act specifically on a subset of
primary afferent sensory neurons to open a novel cation-selective ion channel in the plasma …

The mouse hemisected spinal cord with attached dorsal roots and spinal ganglia in vitro
preparation was used to investigate the effects of the capsaicin antagonist, capsazepine (2 …

Capsazepine block of voltage-activated calcium channels in adult rat dorsal root ganglion
neurones in culture Page 1 Capsazepine block of voltage-activated calcium channels in adult …

The selective excitant and neurotoxic action of capsaicin on vagal sensory neurons in the rat
has been investigated in vitro using three techniques: extracellular recording of compound …

Capsaicin produces pain by selectively activating polymodal nociceptive neurons. This
involves a membrane depolarization and the opening of a unique, cation-selective, ion …

1 The effects of capsaicin on voltage‐gated Ca2+ currents (ICa), and intracellular Ca2+
concentrations ([Ca2+] i) in cultured dorsal root ganglion (DRG) neurones of the rat were …

Capsaicin activates a non-specific cation conductance in mammalian sensory neurones. If
capsaicin is applied continuously or repeatedly then there is a progressive decline in …