The mechanistic relationships between the progression of growth chondrocyte
differentiation, matrix mineralization, oxidative metabolism, and mitochondria content and …

Purpose: Mesenchymal Stem Cells (MSCs) have been promised as therapy for skeletal
diseases such as osteoarthritis (OA) for decades. Some evidence suggests MSCs improve …

Mesenchymal stem cells (MSCs) are progenitors of connective tissues, which have emerged
as important tools for tissue engineering due to their differentiation potential along various …

Cartilage functions at a lower oxygen tension than most other tissues. To determine the role
of oxygen tension in chondrocyte differentiation and function, we investigated the influence …

OBJECTIVE: Here we investigate whether monolayer culture or culture at 21% oxygen
influences activity of cytochrome c oxidase, the terminal enzyme in the respiratory chain …

As the most common form of arthritis, osteoarthritis (OA) has become a major cause of
severe joint pain, physical disability, and quality of life impairment in the affected population …

Accumulation of oxidative damage from excess reactive oxygen species (ROS) may
contribute to skeletal aging and mediate adverse responses to physiological challenges …

Upregulation of matrix metalloproteinases (MMPs) is a hallmark of osteoarthritis
progression; along with the role reactive oxygen species (ROS) may play in this process …

Long bone growth requires the precise control of chondrocyte maturation from proliferation
to hypertrophy during endochondral ossification, but the bioenergetic program that ensures …

Objective Allogeneic mesenchymal stromal cells (MSCs) are used in the 1-stage treatment
of articular cartilage defects. The aim of this study is to investigate whether transport of …