Aim Omapatrilat is an antagonist of angiotensin-converting (ACE) and neprilysin-
neuropeptidase (NEP) enzymes. The aim of our study is to show that omapatrilat may have …

Acute lung injury (ALI) is a common disease characterized by pulmonary inflammation and
oxidative stress. Sinomenine (SIN) is an alkaloid originally extracted from the Chinese …

Objectives Our present study focused on assessing whether Sinomenine (SIN) could
attenuate sepsis-induced acute lung injury (ALI). Methods The mice were conditioned with …

BACKGROUND: Previous reports suggest that NO may contribute to the pathophysiology of
septic shock. Recently, we have synthesized and characterized a series of benzyl-and …

Sepsis causes neutrophil sequestration in the lung, which leads to acute lung injury (ALI).
Neutrophil elastase (NE) is thought to play an important role in the pathogenesis of ALI. This …

Acute lung injury (ALI) is a continuum of lung changes associated with uncontrolled
excessive lung inflammation. However, the pathogenesis of ALI is still complicated and …

Sepsis, a systemic inflammatory response to infection, is the major cause of death in
intensive care units (ICUs). The mortality rate of sepsis remains high even though the …

Sivelestat sodium (SIV), a neutrophil elastase inhibitor, is mainly used for the clinical
treatment of acute respiratory distress syndrome (ARDS) or acute lung injury (ALI). However …

Sepsis is a systemic inflammatory response syndrome caused by a host's immune response
to infection. Acute lung injury (ALI) is one of the most common complications of sepsis with …

Aims To investigate the role and mechanisms of methyltransferase-like 3 (METTL3) in the
pathogenesis of lipopolysaccharide (LPS)-induced acute lung injury (ALI). Main methods …