Biofilm microenvironment-responsive polymeric CO releasing micelles for enhanced amikacin efficacy

Q Zhou, T Wang, K Li, S Zhang, K Wang… - Journal of Controlled …, 2023 - Elsevier
Biofilm-associated infections (BAI) have posed serious threats to public health. Novel
therapy based on carbon monoxide (CO) is being increasingly appreciated. However, CO …

Cationic Carbon Monoxide-Releasing Polymers as Antimicrobial and Antibiofilm Agents by the Synergetic Activity

L Wang, W Zhong, B Liu, D Pranantyo… - … Applied Materials & …, 2023 - ACS Publications
Recent studies indicate that carbon monoxide-releasing molecules (CORMs), a class of
organometallic compounds, exert antibacterial activities through the delivery of carbon …

Quaternary ammonium salt-based cross-linked micelles to combat biofilm

F Liu, D He, Y Yu, L Cheng, S Zhang - Bioconjugate chemistry, 2019 - ACS Publications
Due to self-produced extracellular polymeric substances (EPS), biofilms are hard to
eradicate by common antimicrobials. Herein, a new quaternary ammonium salt based cross …

Methionine-based carbon monoxide releasing polymer for the prevention of biofilm formation

B Maiti, G Ng, A Abramov, C Boyer, DD Díaz - Polymer Chemistry, 2021 - pubs.rsc.org
Carbon monoxide (CO) is being increasingly appreciated as a major physiological
gasomediator and plays significant roles in different biological activities. However, site …

Antibiotic cross-linked micelles with reduced toxicity for multidrug-resistant bacterial sepsis treatment

X Yang, H Ren, H Zhang, G Liu, Z Jiang… - … Applied Materials & …, 2021 - ACS Publications
One potential approach to address the rising threat of antibiotic resistance is through novel
formulations of established drugs. We designed antibiotic cross-linked micelles (ABC …

CO-releasing polymers exert antimicrobial activity

D Nguyen, TK Nguyen, SA Rice, C Boyer - Biomacromolecules, 2015 - ACS Publications
Infectious diseases remain one of the leading causes of death worldwide despite the
tremendous effort devoted to the design and development of antimicrobial agents. However …

Enzyme responsive copolymer micelles enhance the anti-biofilm efficacy of the antiseptic chlorhexidine

YN Albayaty, N Thomas, M Jambhrunkar… - International Journal of …, 2019 - Elsevier
Staphylococcal biofilms cause many infectious diseases and are highly tolerant to the effects
of antimicrobials; this is partly due to the biofilm matrix, which acts as a physical barrier …

Bacterial biofilm destruction by size/surface charge-adaptive micelles

M Chen, J Wei, S Xie, X Tao, Z Zhang, P Ran, X Li - Nanoscale, 2019 - pubs.rsc.org
Biofilms formed by pathogenic bacteria are one of the most important reasons for multidrug
resistance. One of the major limitations in the biofilm treatment is the existence of intensive …

Step-by-step dual stimuli-responsive nanoparticles for efficient bacterial biofilm eradication

Q Fan, C Wang, R Guo, X Jiang, W Li, X Chen… - Biomaterials …, 2021 - pubs.rsc.org
Biofilm-related bacterial infections are extremely resistant to antibiotics, mainly due to the
impermeability of the intensive matrices, which allow the bacteria to survive antibiotic …

Drug delivery approaches for enhanced antibiofilm therapy

T Wang, EJ Cornel, C Li, J Du - Journal of Controlled Release, 2023 - Elsevier
Biofilms have attracted increasing attention in recent years. Many bacterial infections are
associated with biofilm formation. A bacterial biofilm is an aggregated membrane-like …