Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it

AR Jensen, Y Adams, L Hviid - Immunological reviews, 2020 - Wiley Online Library
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …

The role of PfEMP1 as targets of naturally acquired immunity to childhood malaria: prospects for a vaccine

PC Bull, AI Abdi - Parasitology, 2016 - cambridge.org
The Plasmodium falciparum erythrocyte membrane protein 1 antigens that are inserted onto
the surface of P. falciparum infected erythrocytes play a key role both in the pathology of …

PfEMP1: an antigen that plays a key role in the pathogenicity and immune evasion of the malaria parasite Plasmodium falciparum

ND Pasternak, R Dzikowski - The international journal of biochemistry & …, 2009 - Elsevier
The deadliest form of human malaria is caused by the protozoan parasite Plasmodium
falciparum affecting millions worldwide every year. P. falciparum virulence is attributed to its …

PfEMP1–a parasite protein family of key importance in Plasmodium falciparum malaria immunity and pathogenesis

L Hviid, ATR Jensen - Advances in parasitology, 2015 - Elsevier
Plasmodium falciparum causes the most severe form of malaria and is responsible for
essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes …

[HTML][HTML] Surface antigens of Plasmodium falciparum-infected erythrocytes as immune targets and malaria vaccine candidates

JA Chan, FJI Fowkes, JG Beeson - Cellular and Molecular Life Sciences, 2014 - Springer
Understanding the targets and mechanisms of human immunity to malaria caused by
Plasmodium falciparum is crucial for advancing effective vaccines and developing tools for …

[HTML][HTML] Targets of antibodies against Plasmodium falciparum–infected erythrocytes in malaria immunity

JA Chan, KB Howell, L Reiling, R Ataide… - The Journal of …, 2012 - Am Soc Clin Investig
Plasmodium falciparum is the major cause of malaria globally and is transmitted by
mosquitoes. During parasitic development, P. falciparum–infected erythrocytes (P …

Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes

DI Baruch, BL Pasloske, HB Singh, X Bi, XC Ma… - Cell, 1995 - cell.com
Plasmodium falciparum-infected human erythrocytes evade host immunity by expression of
a ceil-surface variant antigen and receptors for adherence to endothelial cells. These …

Sequential, ordered acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 domains

GKK Cham, L Turner, J Lusingu… - The Journal of …, 2009 - journals.aai.org
The binding of erythrocytes infected with mature blood stage parasites to the vascular bed is
key to the pathogenesis of malignant malaria. The binding is mediated by members of …

Evasion of immunity to Plasmodium falciparum malaria by IgM masking of protective IgG epitopes in infected erythrocyte surface-exposed PfEMP1

L Barfod, MB Dalgaard, ST Pleman… - Proceedings of the …, 2011 - National Acad Sciences
Plasmodium falciparum malaria is a major cause of mortality and severe morbidity. Its
virulence is related to the parasite's ability to evade host immunity through clonal antigenic …

Antibodies to variant antigens on the surfaces of infected erythrocytes are associated with protection from malaria in Ghanaian children

D Dodoo, T Staalsoe, H Giha, JAL Kurtzhals… - Infection and …, 2001 - Am Soc Microbiol
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a variant antigen
expressed on the surface of infected erythrocytes. Each parasite genome contains about 40 …