Despite all modern advances in medicine, an effective drug treatment of obesity has not
been found yet. Discovery of leptin two decades ago created hopes for treatment of obesity …

Celastrol, a pentacyclic triterpene, is the most potent antiobesity agent that has been
reported thus far. The mechanism of celastrol's leptin-sensitizing and antiobesity effects has …

Metabolic diseases are becoming increasingly common in modern society. Therefore, it is
essential to develop effective drugs or new treatments for metabolic diseases. As an active …

Objective Celastrol, a triterpene from the root bark of the Chinese medicinal plant
Tripterygium wilfordii, has been shown to exhibit anti-oxidant, anti-inflammatory, anti-cancer …

Celastrol is a natural pentacyclic triterpene used in traditional Chinese medicine with
significant weight-lowering effects. Celastrol-administered mice at 100 μg/kg decrease food …

Obesity is associated with disrupted energy homeostasis and intestinal dysbiosis. Caulis
Spatholobi, traditional Chinese medicine for herbal therapy, contains a wide range of …

Botanical triterpene celastrol is a candidate drug for the treatment of obesity, except for
concerns over the safety in clinical application. The present study was designed to …

Accumulating evidence indicates that adipose tissue inflammation and mitochondrial
dysfunction in skeletal muscle are inextricably linked to obesity and insulin resistance …

High fat diet, as an important risk factor, plays a pivotal role in atherosclerotic process.
Celastrol is one of the active triterpenoid compounds with antioxidative and anti …

Obesity is a global health concern. Piceatannol (Pic), an analog of resveratrol (Res), has
many reported biological activities. In this study, we investigated the anti-obesity effect of Pic …