This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …

Amyloidogenesis has been implicated in a broad spectrum of diseases in which amyloid
protein is invariably misfolded and deposited in cells and organs. Alzheimer's disease is one …

Amyloid formation plays a central role in the cause and progression of Alzheimer's disease.
The major component of this amyloid is the amyloid‐β (Aβ) peptide, which is currently the …

Conspectus In the more than a century since its identification, Alzheimer's disease has
become the archetype of amyloid diseases. The first glimpses of the chemical basis of …

Synthetic peptides containing the sequence of Alzheimer's amyloid-β peptide (Aβ)
spontaneously form amyloid-like fibrils in vitro, and have been extensively used to study the …

Alzheimer's disease (AD) pathogenesis is widely believed to be driven by the production
and deposition of the amyloid-β peptide (Aβ). For many years, investigators have been …

Publisher Summary The immense difficulties and unexpected questions presented by
hundreds of amyloid toxicity studies beg for a careful study of Aβ assembly processes …

The ability to form stable cross‐β fibrils is an intrinsic physicochemical characteristic of the
human β‐amyloid peptide (Aβ), which forms the brain amyloid of Alzheimer's disease (AD) …

The chemistry of Alzheimer’s disease - Chemical Society Reviews (RSC Publishing) DOI:10.1039/B807980N
Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article DOI: 10.1039/B807980N …

Amyloid β-peptide (Aβ) is a major fibrillar component of neuritic plaques in Alzheimer's
disease (AD) brains and is related to the pathogenesis of the disease. We hypothesized that …