Blood is the pipeline of the immune system. Assessing changes in transcript abundance in
blood on a genome-wide scale affords a comprehensive view of the status of the immune …

The immune system plays a key role in health maintenance and pathogenesis of a wide
range of diseases. Leukocytes that are present in the blood convey valuable information …

As the capacity for generating large-scale molecular profiling data continues to grow, the
ability to extract meaningful biological knowledge from it remains a limitation. Here, we …

Transcriptomics, the high-throughput characterization of RNAs, has been instrumental in
defining pathogenic signatures in human autoimmunity and autoinflammation. It enabled the …

Gene expression profiling in clinical genomics has yet to deliver robust and reliable
approaches for developing diagnostics and contributing to personalized medicine. Owing to …

The immune system plays a vital role in health and disease, and is regulated through a
complex interactive network of many different immune cells and mediators. To understand …

Background The molecular profile of circulating blood can reflect physiological and
pathological events occurring in other tissues and organs of the body and delivers a …

BACKGROUND The mammalian immune system is a remarkable sensory system for the
detection and neutralization of pathogens. History is replete with the devastating effects of …

Motivation: Although a huge amount of mammalian genomic data does become publicly
available, there are still hurdles for biologists to overcome before such data can be fully …

Recent innovation in high-throughput sequencing technologies has drastically empowered
the scientific research. Consequently, now, it is possible to capture comprehensive profiles …