Advanced strategies in improving the immunotherapeutic effect of CAR‐T cell therapy

M Wang, L Jia, X Dai, X Zhang - Molecular Oncology, 2024 - Wiley Online Library
Chimeric antigen receptor (CAR‐T) cell therapy is a newly developed immunotherapy
strategy and has achieved satisfactory outcomes in the treatment of hematological …

[HTML][HTML] CAR-T in cancer treatment: Develop in self-optimization, win-win in cooperation

F Guo, J Cui - Cancers, 2021 - mdpi.com
Simple Summary Chimeric antigen receptor (CAR)-T cell therapy has exhibited good
application prospects in the treatment of hematologic malignancies. However, there are still …

[HTML][HTML] Current challenges and therapeutic advances of CAR-T cell therapy for solid tumors

T Chen, M Wang, Y Chen, Y Liu - Cancer Cell International, 2024 - Springer
The application of chimeric antigen receptor (CAR) T cells in the management of
hematological malignancies has emerged as a noteworthy therapeutic breakthrough …

[HTML][HTML] CAR‑T cell therapy: A breakthrough in traditional cancer treatment strategies

D Sun, X Shi, S Li, X Wang… - Molecular Medicine …, 2024 - spandidos-publications.com
Chimeric antigen receptor (CAR)-T cell therapy is an innovative approach to immune cell
therapy that works by modifying the T cells of a patient to express the CAR protein on their …

Paving the road to make chimeric antigen receptor‐T‐cell therapy effective against solid tumors

K Adachi, K Tamada - Cancer Science, 2022 - Wiley Online Library
The three major standard therapies, that is, surgery, chemotherapy, and radiation therapy
have conventionally been applied to the treatments for cancers and have saved many …

CAR T‑cell immunotherapy: A safe and potent living drug technique for cancer treatment

A Ahmad, M Haneef, SA Khan… - World Academy of …, 2023 - spandidos-publications.com
For several decades, surgery, chemotherapy and radiation therapy have been the
fundamental components of cancer treatment. Although these represent key therapeutic …

[HTML][HTML] Evolving CAR-T-Cell Therapy for Cancer Treatment: From Scientific Discovery to Cures

A Majumder - Cancers, 2023 - mdpi.com
Simple Summary It is well recognized now that the development of drug resistance is one of
the leading causes of treatment failure in conventional therapies. In comparison, recent …

[HTML][HTML] Efficacy, safety, and challenges of CAR T-cells in the treatment of solid tumors

Q Chen, L Lu, W Ma - Cancers, 2022 - mdpi.com
Simple Summary Chimeric antigen receptor T cells (CAR T-cells) are engineered T cells that
target tumor-associated antigens. CAR T-cell therapy is a novel developed immunotherapy …

[HTML][HTML] CAR T-cells: novel therapeutic approaches in the new era of cancer immunotherapy

A Turdo, CM Cristiani, N Schaft - Frontiers in Molecular Medicine, 2023 - frontiersin.org
Immunotherapy has emerged as one of the most effective treatments capable of overcoming
tumor resistance mechanisms due to its ability to modulate the patient's immune response …

[HTML][HTML] Hurdles of CAR-T cell-based cancer immunotherapy directed against solid tumors

BL Zhang, DY Qin, ZM Mo, Y Li, W Wei… - Science China Life …, 2016 - Springer
Recent reports on the impressive efficacy of chimeric antigen receptor (CAR)-modified T
cells against hematologic malignancies have inspired oncologists to extend these efforts for …