Retinitis pigmentosa and Leber congenital amaurosis are inherited retinal dystrophies that
can be caused by mutations in the Crumbs homolog 1 (CRB1) gene. CRB1 is required for …

Mutations in the Crumbs-homologue-1 (CRB1) gene lead to severe recessive inherited
retinal dystrophies. Gene transfer therapy is the most promising cure for retinal dystrophies …

Loss of Crumbs homolog 1 (CRB1) or CRB2 proteins in Müller cells or photoreceptors in the
mouse retina results in a CRB dose-dependent retinal phenotype. In this study, we present a …

Despite their physiological roles, Müller glial cells are involved directly or indirectly in retinal
disease pathogenesis and are an interesting target for therapeutic approaches for retinal …

Mutations in the photoreceptor transcription factor gene cone-rod homeobox (CRX) lead to
distinct retinopathy phenotypes, including early-onset vision impairment in dominant Leber …

In humans, the Crumbs homolog-1 (CRB1) gene is mutated in autosomal recessive Leber
congenital amaurosis and early-onset retinitis pigmentosa. In mammals, the Crumbs family …

Human retinal organoids from induced pluripotent stem cells (hiPSCs) can be used to
confirm the localization of proteins in retinal cell types and to test transduction and …

Variations in the human Crumbs homolog-1 (CRB1) gene lead to an array of retinal
dystrophies including early onset of retinitis pigmentosa (RP) and Leber congenital …

Development in the central nervous system is highly dependent on the regulation of the
switch from progenitor cell proliferation to differentiation, but the molecular and cellular …

Different mutations in the human Crumbs homolog-1 (CRB1) gene cause a variety of retinal
dystrophies, such as Leber congenital amaurosis, early onset retinitis pigmentosa (eg …