Docosahexaenoic and eicosapentaenoic acids segregate differently between raft and nonraft domains

JA Williams, SE Batten, M Harris, BD Rockett… - Biophysical journal, 2012 - cell.com
Omega-3 polyunsaturated fatty acids (n-3 PUFA), enriched in fish oils, are increasingly
recognized to have potential benefits for treating many human afflictions. Despite the …

Biophysical and biochemical mechanisms by which dietary N-3 polyunsaturated fatty acids from fish oil disrupt membrane lipid rafts

SR Shaikh - The Journal of nutritional biochemistry, 2012 - Elsevier
N-3 polyunsaturated fatty acids (PUFAs) from fish oil exert their functional effects by targeting
multiple mechanisms. One mechanism to emerge in the past decade is the ability of n-3 …

Docosahexaenoic acid regulates the formation of lipid rafts: A unified view from experiment and simulation

SR Wassall, X Leng, SW Canner… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Abstract Docosahexaenoic acid (DHA, 22: 6) is an n− 3 polyunsaturated fatty acid (n− 3
PUFA) that influences immunological, metabolic, and neurological responses through …

[HTML][HTML] How polyunsaturated fatty acids modify molecular organization in membranes: insight from NMR studies of model systems

SR Shaikh, JJ Kinnun, X Leng, JA Williams… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Marine long chain n-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic (EPA) and
docosahexaenoic acid (DHA), are bioactive molecules with clinical applications for the …

n− 3 PUFA and membrane microdomains: a new frontier in bioactive lipid research

DWL Ma, J Seo, KC Switzer, YY Fan… - The Journal of nutritional …, 2004 - Elsevier
In recent years, our understanding of the plasma membrane has changed considerably as
our knowledge of lipid microdomains has expanded. Lipid microdomains include structures …

Docosahexaenoic acid domains: the ultimate non-raft membrane domain

SR Wassall, W Stillwell - Chemistry and physics of lipids, 2008 - Elsevier
What distinguishes polyunsaturated fatty acids (PUFAs) from less unsaturated fatty acids is
the presence of a repeating CH–CH2–CH unit that produces an extremely flexible structure …

All n-3 PUFA are not the same: MD simulations reveal differences in membrane organization for EPA, DHA and DPA

X Leng, JJ Kinnun, AT Cavazos, SW Canner… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Abstract Eicosapentaenoic (EPA, 20: 5), docosahexaenoic (DHA, 22: 6) and
docosapentaenoic (DPA, 22: 5) acids are omega-3 polyunsaturated fatty acids (n-3 PUFA) …

n− 3 Polyunsaturated fatty acids exert immunomodulatory effects on lymphocytes by targeting plasma membrane molecular organization

SR Shaikh, CA Jolly, RS Chapkin - Molecular aspects of medicine, 2012 - Elsevier
Fish oil, enriched in bioactive n− 3 polyunsaturated fatty acids (PUFA), has therapeutic value
for the treatment of inflammation-associated disorders. The effects of n− 3 PUFAs are …

[HTML][HTML] Dietary (n-3) polyunsaturated fatty acids remodel mouse T-cell lipid rafts

YY Fan, DN McMurray, LH Ly, RS Chapkin - The Journal of nutrition, 2003 - Elsevier
In vitro evidence indicates that (n-3) polyunsaturated fatty acids (PUFA) suppress T-cell
activation in part by displacing proteins from lipid rafts, specialized regions within the plasma …

Docosahexaenoic acid enhances segregation of lipids between raft and nonraft domains: 2H-NMR study

SP Soni, DS LoCascio, Y Liu, JA Williams, R Bittman… - Biophysical journal, 2008 - cell.com
Solid-state 2 H-NMR of [2 H 31]-N-palmitoylsphingomyelin ([2 H 31] 16: 0SM, PSM*),
supplemented by differential scanning calorimetry, was used for the first time, to our …