Metabolic and monocyte-suppressing actions of fenofibrate in patients with mixed dyslipidemia and early glucose metabolism disturbances

R Krysiak, A Stachura-Kułach, B Okopień - Pharmacological Reports, 2010 - Springer
The aim of this study was to compare the action of fenofibrate on monocyte cytokine release
between patients with isolated mixed dyslipidemia and dyslipidemia coexisting …

Fenofibrate reduces fasting and postprandial inflammatory responses among hypertriglyceridemia patients with the metabolic syndrome

RS Rosenson, AL Huskin, DA Wolff, IB Helenowski… - Atherosclerosis, 2008 - Elsevier
OBJECTIVE: To examine the effects of fenofibrate (160mg/d) therapy on fasting and
postprandial cytokine production in subjects with metabolic syndrome and …

Effects of short-term fenofibrate treatment on circulating markers of inflammation and hemostasis in patients with impaired glucose tolerance

B Okopien, R Krysiak, ZS Herman - The Journal of Clinical …, 2006 - academic.oup.com
Context: Apart from lowering lipid levels, peroxisome proliferator-activated receptor (PPAR)
α activators (fibrates) produce many other favorable effects that may contribute to their …

Monocyte-suppressing effect of high-dose metformin in fenofibrate-treated patients with impaired glucose tolerance

R Krysiak, A Gdula-Dymek, B Okopień - Pharmacological Reports, 2013 - Elsevier
Background Fibrates were found to reduce cytokine release and low-grade inflammation in
patients with impaired glucose tolerance. The aim of this study was to investigate whether …

Effect of bezafibrate on monocyte cytokine release and systemic inflammation in patients with impaired fasting glucose

R Krysiak, B Okopien - The Journal of Clinical Pharmacology, 2011 - Wiley Online Library
This study assessed the effect of bezafibrate on monocyte secretory function and systemic
inflammation in patients with impaired fasting glucose (IFG), comparing this effect with that …

Monocyte‐suppressing effect of bezafibrate but not omega‐3 fatty acids in patients with isolated hypertriglyceridaemia

R Krysiak, A Gdula‐Dymek… - Basic & clinical …, 2011 - Wiley Online Library
Fibrates and omega‐3 fatty acids have been used for many years in the treatment of
increased triglyceride levels. Unfortunately, pleiotropic effects of these agents in patients …

Monocyte suppressing action of fenofibrate.

B Okopień, J Kowalski, R Krysiak… - Pharmacological …, 2005 - europepmc.org
Since atherosclerosis has been proven to be an inflammatory disease, it is obvious that the
proper treatment for dyslipidemia should not only correct lipid parameters but also inhibit …

Micronized fenofibrate normalizes the enhanced lipidemic response to a fat load in patients with type 2 diabetes and optimal glucose control

E Cavallero, C Dachet, F Assadolahi, C Martin… - Atherosclerosis, 2003 - Elsevier
This study evaluated the postprandial (PP) response to an oral fat load in 28 male patients
with type 2 diabetes (mean HbA1c of 5.1%), all receiving metformin and performing physical …

Hemostatic effects of fenofibrate in patients with mixed dyslipidemia and impaired fasting glucose

R Krysiak, G Handzlik, B Okopień - Pharmacological Reports, 2010 - Springer
Our study aimed to compare the effect of fenofibrate on hemostasis between patients with
isolated impaired fasting glucose (IFG) and isolated mixed dyslipidemia and to examine the …

The influence of fenofibrate on lipid profile, endothelial dysfunction, and inflammatory markers in type 2 diabetes mellitus patients with typical and mixed dyslipidemia

RA Ghani, IB Yaakob, NA Wahab, S Zainudin… - Journal of clinical …, 2013 - Elsevier
Background Type 2 diabetes is associated with early development of endothelial
dysfunction. Patients present with typical dyslipidemia (predominantly high levels of …