Pioneering electron microscopy studies defined two primary populations of ribosomes in
eukaryotic cells: one freely dispersed through the cytoplasm and the other bound to the …

In eukaryotic cells, the spatial regulation of protein expression is frequently conferred
through the coupling of mRNA localization and the local control of translation. mRNA …

In eukaryotic cells, it is generally accepted that protein synthesis is compartmentalized;
soluble proteins are synthesized on free ribosomes, whereas secretory and membrane …

It is well established that mRNAs encoding secretory or membrane-bound proteins are
translated on the surface of the endoplasmic reticulum (ER). The extent to which mRNAs that …

In eukaryotic cells, protein synthesis is compartmentalized; mRNAs encoding
secretory/membrane proteins are translated on endoplasmic reticulum (ER)-bound …

Ribosomes are highly conserved macromolecular machines that are responsible for protein
synthesis in all living organisms. Work published in the past year has shown that changes to …

Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather
than intrinsic regulatory capacity in mRNA translation. However, emerging studies reveal …

Emerging studies have linked the ribosome to more selective control of gene regulation.
However, an outstanding question is whether ribosome heterogeneity at the level of core …

In metazoans, the majority of mRNAs coding for secreted and membrane-bound proteins are
translated on the surface of the endoplasmic reticulum (ER). Although the targeting of these …

In current views, translation-coupled ribosome binding to the endoplasmic reticulum (ER)
membrane is transient, with association occurring via the signal recognition particle pathway …