Increased fat storage in adipose and non-adipose tissue (eg skeletal muscle) characterizes
the obese insulin resistant state. Disturbances in pathways of lipolysis may play a role in the …

The mobilization of fat stored in adipose tissue is mediated by hormone-sensitive lipase
(HSL) and the recently characterized adipose triglyceride lipase (ATGL), yet their relative …

Adipose tissue lipolysis is the catabolic process leading to the breakdown of triglycerides
stored in fat cells and the release of fatty acids and glycerol. Recent work has revealed that …

Hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) regulate adipocyte
lipolysis in rodents. The purpose of this study was to compare the roles of these lipases for …

In white adipose tissue, lipolysis can occur by hormone-sensitive lipase (HSL)-dependent or
HSL-independent pathways. To study HSL-independent lipolysis, we placed HSL-deficient …

Catecholamines are the only hormones with pronounced lipolytic action in man. A number of
in vivo and in vitro studies suggest that there is lipolytic resistance to catecholamines in …

Decreased lipolytic effect of catecholamines in adipose tissue has repeatedly been
demonstrated in obesity and may be a cause of excess accumulation of body fat. However …

Objective: To directly ascertain the physiological roles in adipocytes of hormone‐sensitive
lipase (HSL; EC 3.1. 1.3), a multifunctional hydrolase that can mediate triacylglycerol …

Catecholamines and natriuretic peptides stimulate human adipocyte lipolysis through an
increase in cAMP and cGMP levels, resulting in phosphorylation and activation of hormone …

In comparison to subcutaneous (SC) fat, visceral adipose tissue is more sensitive to
catecholamine-induced lipolysis and less sensitive to the antilipolytic effects of insulin …