Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolysis of cyclic AMP and
cyclic GMP, thereby regulating the intracellular concentrations of these cyclic nucleotides …

Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that regulate the cellular levels
of the second messengers, cAMP and cGMP, by controlling their rates of degradation. There …

The superfamily of cyclic nucleotide (cN) phosphodiesterases (PDEs) is comprised of 11
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …

Cyclic nucleotide phosphodiesterases (PDEs) comprise a superfamily of
metallophosphohydrolases that specifically cleave the 3′, 5′-cyclic phosphate moiety of …

The establishment of a Gordon Research Conference devoted to cyclic nucleotide
phosphodiesterases has had an enormous impact on the field by facilitating collaborations …

Phosphodiesterases (PDEs), enzymes that degrade 3′, 5′-cyclic nucleotides, are being
pursued as therapeutic targets for several diseases, including those affecting the nervous …

Cyclic nucleotide phosphodiesterases (PDEs) form an 11-member superfamily comprising
100 different isoforms that regulate the second messengers cyclic adenosine or guanosine …

Cyclic nucleotide phosphodiesterases (PDEs) that specifically inactivate the intracellular
messengers cAMP and cGMP in a compartmentalized manner represent an important …

Cyclic adenosine 3'5'-monophosphate (cAMP) and cyclic guanosine 3'5'-monophoshpate
(cGMP) are critical intracellular second-messengers involved in the transduction of a wide …

The nucleotides cyclic adenosine 3′, 5′-monophosphate (cAMP, 1; Chart 1) and cyclic
guanosine 3′, 5′-monophosphate (cGMP, 2) are intracellular second messengers that …