Objective Ovarian cancer is the leading cause of gynecologic-related mortality worldwide.
Despite successful initial treatment, overall survival rates are very low because tumors …

Abstract Purpose The PI3K/AKT/mTOR pathway is one of the most highly activated cellular
signaling pathways in advanced ovarian cancer. Although several PI3K/AKT/mTOR …

Abstract The phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
signaling pathway is frequently mutated in cancers, leading to increased cell proliferation …

Background Ovarian cancer is the major cause of death from gynaecological malignancy
with a 5 year survival of only∼ 30% due to resistance to platinum and paclitaxel-based first …

Activation of the PI3K/mTOR pathway has been shown to be correlated with resistance to
chemotherapy in ovarian cancer. We aimed to investigate the effects of combining inhibition …

Background Ovarian cancer is one of the major causes of death in women worldwide.
Despite improvements in conventional treatment approaches, such as surgery and …

The activation of the PI3K/AKT/mTOR pathway plays a key role in ovarian cancer
tumorigenesis, progression and chemotherapy resistance. This study aimed to explore the …

The phosphatidylinositol 3 kinase (PI3K) pathway is frequently altered in cancer, including
ovarian cancer (OC). Unfortunately, despite a sound biological rationale and encouraging …

Ovarian cancer (OC) is a lethal gynecological cancer. The phosphatidylinositol 3-kinase
(PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway plays an important …

OBJECTIVE: This study was to investigate the role of the PI3K/AKT/mTOR/Survivin signaling
in epithelial ovarian cancer development and its mechanism in cisplatin-based …