Introduction Studies examining the effect of polygenic risk scores (PRS) for Alzheimer's
disease (AD) and apolipoprotein E (APOE) genotype on incident dementia in very old …

Background In order to utilize polygenic risk scores (PRSs) for Alzheimer's disease (AD) in a
meaningful way, influential factors (ie training set) and prediction across groups such as …

Background Both family aggregation and apolipoprotein E (APOE) ε4 allele are well-known
risk factors for dementia, but the relation between these two factors remains unclear …

Introduction We investigated relationships among genetic determinants of Alzheimer's
disease (AD), amyloid/tau/neurodegenaration (ATN) biomarkers, and risk of dementia …

The We and others have previously shown that polygenic risk score analysis (PRS) has
considerable predictive utility for identifying those at high risk of developing Alzheimer's …

To evaluate how age and apolipoprotein E-ε4 (APOE4) status interact with APOE-
independent polygenic risk score (PRS non-APOE), we estimated PRS non-APOE in …

Few studies have measured the effect of genetic factors on dementia and cognitive decline
in healthy older individuals followed prospectively. We studied cumulative incidence of …

Background The objective of this study was to analyze factors influencing the risk and timing
of Alzheimer's disease (AD) in central Norway. The APOE ε4 allele is the only consistently …

Objectives To provide risk estimates of dementia and Alzheimer disease as a function of the
apolipoprotein E (APOE) genotypes and to assess the proportion of dementia that is …

Background: Apolipoprotein E (APOE) polymorphisms are unequivocally associated with
risk for Alzheimer's disease (AD). It is crucial to understand how this genetic factor affects …